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High-resolution sequencing methods that capture the epigenetic landscape within the T cell receptor (TCR) gene loci are pivotal for a fundamental understanding of the epigenetic regulatory mechanisms of the TCR repertoire. In our opinion, filling the gaps in our understanding of the epigenetic mechanisms regulating the TCR repertoire will benefit the development of strategies that can modulate the TCR repertoire composition by leveraging the dynamic nature of epigenetic modifications.
An approach combining in situ tagmentation and transcription with MERFISH enables spatial profiling of the epigenome in tissues with single-cell resolution.
A rapidly evolving toolbox is helping researchers to get a handle on the biological and functional diversity of these ubiquitous — but still somewhat enigmatic — cell-secreted nanoparticles
Researchers use electric fields to transfer RNA from a tissue sample onto a surface for subsequent fluorescence in situ hybridization-based profiling of transcriptomes at the single-cell level.
Harvester ants live in desert grasslands and eat seeds. Colonies manage water stress by regulating foraging using olfactory interactions between outgoing and returning foragers. A long-term study in New Mexico shows how this collective behavior is evolving in drought conditions.
Research interest in noncoding RNAs and their biological implications in a variety of cellular contexts has been growing. In this issue, we present a series of pieces discussing recent method advances and future directions for deciphering the regulatory roles of noncoding RNAs.