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GFP targeted to satellite repeats via transcription activator–like effectors (TALEs) allows the imaging of nuclear dynamics early in mouse development.
Imaging with better than 200-nanometer resolution brings new subcellular-scale details into focus. Practitioners share how they weigh trade-offs in speed, resolution and phototoxicity.
Transcription activator–like effectors (TALEs) fused to enzymes that change chromatin signatures interrogate the role of enhancers in gene expression.