Thompson, O. et al. Genome Res. 23, 1749–1762 (2013).

In a joint effort, researchers at one US and two Canadian institutions created 2,007 mutagenized Caenorhabditis elegans strains with alterations in each of the worm's more than 20,000 genes. Exposing the nematodes to a combination of two chemical mutagens and then selecting and propagating them for ten generations resulted in homozygous mutant strains with different types of mutations such as single-nucleotide variants, insertions and deletions, or large chromosome rearrangements. The researchers mapped each mutation to the worm genome to infer its effect. This resource will allow detailed studies of the role of particular genes in worm physiology. The Caenorhabditis Genetics Center will distribute the strains, and all sequences are available from WormBase.