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    Greater specialization means the culture gap between art and science has perhaps never been so extreme. It is hard to find today a true artist- scientist like Leonardo da Vinci, as noted for his science and engineering skills as his Mona LisaandLast Supper. There is just too much to know. But recently there has been an increasing awareness on the part of some artists of the heritage of scientists and vice versa. This supplement aims to reflect, and place in context, some of this awareness.

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    In 1905, Albert Einstein submitted five papers for publication in Annalen der Physik, covering three topics: the photoelectric effect, brownian motion, and the special theory of relativity. Although diverse in subject matter, these contributions are landmarks in their field - and testament to Einstein's genius. To honour their centenary, 2005 has been designated 'World Year of Physics'.Naturejoins the celebrations with the publication of this special supplement.

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    Australia has been a quiet player on the international biotech scene, but in recent years it has been taking strides to reinvent itself as tomorrow's young entrepreneur. This supplement to Naturecharts that transformation.

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    This Collection of articles is unprecedented: a Naturesupplement that was written for researchers in China and originally published, at the end of last year, in the Chinese language.

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    As a prelude to the many celebrations around the world saluting the 50th anniversary of the discovery of the DNA double helix, Nature presents a Collection of overviews that celebrate the historical, scientific and cultural impacts of a revelatory molecular structure.

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    The dominant science hubs in Scandinavia are akin to the open sandwiches favoured throughout the Nordic region - each country has its own name for, and unique approach to preparing, this delicacy. So, too, with science. Each hub has had different motivations and methods for building up local networks, as articles in this supplement reveal.

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    The Alliance for Cellular Signaling (AfCS) is a multidisciplinary, multi-institutional consortium designed to answer global questions about cell- signalling networks. By investigating pathways in B lymphocytes and cardiac myocytes, the AfCS aims to facilitate quantitative modelling and catalyse complementary research, as described in this Collection of papers.

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    By tapping a reservoir of ethnic Chinese scientists in the United States, the tiny island of Taiwan has achieved a global presence in the electronics industry. Substantial investment funds are now available to support new industries such as genomics and biochips. Although lacking the infrastructure to develop these industries, interaction between Chinese scientists in Taiwan, the United States and mainland China could bring Taiwan onto the map in biotechnology.

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    Forecasting the future in science is fun but often hopelessly misleading. This publication, commissioned by all the Naturejournals, focuses on future developments about which we can be reasonably confident and which will have an impact on the lives of all of us.

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    Throughout its 130-year history, Naturehas provided readers with news and comment about scientific careers. ThisNatureCollection provides a repository of invaluable websites and other data essential for the serious jobhunter who wants just the right opportunity.

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    The progress that has been made in the last decades in understanding the biology of the nervous system is extraordinary, and nowhere is this more immediately relevant than in the understanding and treatment of neurological disorders. Thus, we believe that this supplement is both timely and important to our readership.