Genomic analysis articles within Nature

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• News & Views | 31 March 2010

  Genome-wide view of mitosis

  An exceptionally large-scale project aimed at assigning function to all protein-coding genes in the human genome is reported on page 721 by Neumann et al.¹. Here are two complementary views on the experimental design and analysis, and on how useful the findings will be to cell biologists.

  • Jason R. Swedlow
  • , Cecilia Cotta-Ramusino
  •  & Stephen J. Elledge

• Letter | 17 March 2010

  Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication

  An extensive genome-wide survey of over 48,000 single nucleotide polymorphisms in dogs and their wild progenitor, the grey wolf, was conducted to shed light on the process of dog diversification. The results reveal that much of genome diversity came from Middle Eastern progenitors, combined with interbreeding with local wolf populations, and that recent evolution involved limited genetic variation to create the phenotypic diversity of modern dogs.

  • Bridgett M. vonHoldt
  • , John P. Pollinger
  •  & Robert K. Wayne

• Letter | 11 March 2010

  Systematic genetic analysis of muscle morphogenesis and function in Drosophila

  A genome-wide RNA interference screen to systematically test the genetic basis for formation and function of the Drosophila muscle is described. A role in muscle for 2,785 genes is identified; many of these genes are phylogenetically conserved.

  • Frank Schnorrer
  • , Cornelia Schönbauer
  •  & Barry J. Dickson

• News | 20 February 2010

  Junk DNA holds clues to heart disease

  Deleting a non-coding region leads to narrowing of arteries in mice.

  • Janet Fang