Genome-wide analysis of gene expression articles within Nature

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• Article | 04 November 2020

  Neuronal diversity and convergence in a visual system developmental atlas

  The neuronal diversity of the Drosophila optic lobe is described throughout pupal development by single-cell sequencing, leading to the discovery of transient extrinsic neurons and a dorsoventral asymmetry of the visual circuits.

  • Mehmet Neset Özel
  • , Félix Simon
  •  & Claude Desplan

• Letter | 14 March 2018

  The cis-regulatory dynamics of embryonic development at single-cell resolution

  An improved assay for chromatin accessibility at single-cell resolution in Drosophila melanogaster embryos enables identification of developmental-stage- and cell-lineage-specific patterns of chromatin-level transcriptional regulation.

  • Darren A. Cusanovich
  • , James P. Reddington
  •  & Eileen E. M. Furlong

• Letter | 25 September 2017

  Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites

  Highly parallel single-cell transcriptome profiling of Plasmodium falciparum blood stages provides insight into the role AP2-G plays in early sexual development of this eukaryotic pathogen.

  • Asaf Poran
  • , Christopher Nötzel
  •  & Björn F. C. Kafsack

• Letter | 08 June 2016

  Dissecting direct reprogramming from fibroblast to neuron using single-cell RNA-seq

  The transcriptome changes driving the conversion of fibroblasts to neurons at the single-cell level are reported, revealing that early neuronal reprogramming steps are homogenous, driven by the proneural pioneer factor Ascl1; the expression of myogenic genes then has a dampening effect on efficiency, which needs to be counteracted by the neuronal factors Myt1l and Brn2 for more efficient reprogramming.

  • Barbara Treutlein
  • , Qian Yi Lee
  •  & Stephen R. Quake

• Article | 11 May 2016

  Synchronized mitochondrial and cytosolic translation programs

  The genes encoding the subunits of oxidative phosphorylation complexes are split between the nuclear and mitochondrial genomes, but their translation is synchronized by signalling from the cytosol to the mitochondria.

  • Mary T. Couvillion
  • , Iliana C. Soto
  •  & L. Stirling Churchman

• News & Views | 31 March 2010

  Genome-wide view of mitosis

  An exceptionally large-scale project aimed at assigning function to all protein-coding genes in the human genome is reported on page 721 by Neumann et al.¹. Here are two complementary views on the experimental design and analysis, and on how useful the findings will be to cell biologists.

  • Jason R. Swedlow
  • , Cecilia Cotta-Ramusino
  •  & Stephen J. Elledge

• Letter | 17 March 2010

  Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication

  An extensive genome-wide survey of over 48,000 single nucleotide polymorphisms in dogs and their wild progenitor, the grey wolf, was conducted to shed light on the process of dog diversification. The results reveal that much of genome diversity came from Middle Eastern progenitors, combined with interbreeding with local wolf populations, and that recent evolution involved limited genetic variation to create the phenotypic diversity of modern dogs.

  • Bridgett M. vonHoldt
  • , John P. Pollinger
  •  & Robert K. Wayne