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Gurwitz and colleagues propose that consortia dedicated to archiving and analysing data on associations between genotypes and drug-response phenotypes could allow the potential of personalized medicine to be realized, and discuss the associated practical and ethical issues that need to be addressed.
Microwave-assisted organic synthesis has considerable potential to accelerate the generation and optimization of lead compounds. Kappe and Dallinger outline the fundamental principles of this technology and discuss its applications in drug discovery.