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Multi-omics analyses of gut microbiome, liver and blood samples from patients with hepatitis C infection before and after removal of the virus reveal metabolic dysregulation along the gut–liver axis.
This Resource combines amplicon sequencing, shotgun metagenomic sequencing and untargeted metabolomics to provide a global view of microbial–metabolite associations across Earth’s environments.
Genomic analyses of Klebsiella isolates sampled from multiple human, animal and environmental sources in Northern Italy explore Klebsiella population diversity and show that transmission of multidrug-resistant clones between clinical and environmental settings is scarce.
Gold-standard evidence for correlates of protection is provided by analysis of a randomized phase 3 trial of Ad26.COV2.S for protection against moderate to severe-critical COVID-19 disease.
Aerobic methanotrophy is a rare trait, yet bacteria with this capacity are key players in the global methane cycle. Here the authors find a methanotrophic Mycobacterium in a cave, indicating that methane utilization is more widespread across bacteria than previously assumed.
Single-cell measurements and modelling show that the cyanobacterium Prochlorococcus obtain most of the carbon required for growth from mixotrophy, extending their ecological range and impact in the water column.
Recently discovered type III-E CRISPR–Cas systems use the single Cas7-11 effector to cleave foreign RNA. Here the authors use cryo-electron microscopy and biochemical approaches to reveal the mechanisms underlying crRNA maturation, target RNA recognition and cleavage, and communication with the protease Csx29 by Cas7-11.
Production of the enterotoxin tilimycin by gut-resident Klebsiella species can alter gut microbiota composition, induce mutational evolution and drive the emergence of antibiotic resistance in mice.