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IFITM1 can compete with EBV glycoproteins for EphA2 binding and prevent virus entry into epithelial cells, in vitro and in vivo. YTHDF3 suppresses IFITM1 via the degradation-related protein DDX5.
Comparing infection routes and subsequent transmission of MPXV in the multimammate rat (Mastomys natalensis) indicates increased susceptibility, shedding and transmission via the genital mucosae.
Antibiotics to treat carbapenem-resistant Acinetobacter baumannii infection are an urgent need. The cerastecins are potent, bactericidal and efficacious in animal models of infection, and may enable new treatment modalities targeting LOS transport.
Targeted accurate RNA consensus sequencing enables study of de novo errors caused by RNA-dependent RNA polymerases and provides deeper insights into how SARS-CoV-2 genetic diversity emerges.
Nematode signals such as ascarosides are sensed by G protein-coupled receptors of a nematode-trapping fungus, resulting in fungal activation of cAMP–PKA signalling and trap development.
Diet switching from high-fat to standard diet before influenza vaccination affects the metabolic state of T cells, restores their responses and improves vaccine efficacy in mice.
Artemisinin-resistant Plasmodium falciparum can use tRNA modification reprogramming and codon bias translation as an epitranscriptomic response to survive artemisinin-induced stress.
CryoEM of the Salmonella MS- and C-rings in a counterclockwise pose and the C-ring in clockwise poses reveal structural insight into the mechanisms of directional switches and torque transmission for the bacterial flagellar supercomplex.
Age-specific differences upon SARS-CoV-2 infection are marked by emergence of goblet 2 inflammatory cells expressing antiviral interferon stimulating genes in paediatric nasal cultures, and basaloid-like cells with increased viral spread in cultures from older adults.
The presence of multiple functional m6A modification sites on diverse HIV-1 RNA transcripts suggests a strategy to provide additional stability and resilience to HIV-1 replication.
Active infections of giant viruses in their marine protists hosts are tracked at single-cell resolution, showing that, despite being rare, these viruses still impact microbial population dynamics.
The dihydrofolate reductase inhibitor, fluorofolin, shows potent activity against Pseudomonas aeruginosa and selectively eliminates P. aeruginosa from mixed-species bacterial cultures.
The authors propose a model for the mechanism underlying how a phage defence system remains primed for infection but tightly controlled to prevent host toxicity.
A membrane- and DNA-targeting approach is used to design a compound that displays potent activity against multidrug-resistant fungal pathogens without inducing antifungal resistance.
Longitudinal profiling of the nasal and faecal microbiomes of 66 dairy farmers and 166 dairy cows over a year-long period shows that microbes acquired from cow microbiomes introduce clinically relevant antimicrobial resistance genes to farmer guts.
Prophage-encoded anti-phage defence systems in Staphylococcus aureus protect hosts from superinfection but also prevent autoimmunity via an overlapping gene.
Virological, clinical and immunological characterization of a dengue virus 3 human challenge model could help with identifying vaccine and drug candidates.