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Two new approaches to neurochemical monitoring in vivo—an improved real-time microsensor and genetically engineered cells that sense neurotransmitter levels—address the critical issue of brain reactivity to implanted devices.
A surprisingly simple method provides an effective way of correcting optical distortions in two-photon fluorescence microscopy and recovers nearly ideal images of inhomogeneous thick samples.
By grouping short reads derived from the same long genomic fragment, the reads can easily be assembled into fragments that approach the length of capillary sequencing reads.
Cardiomyocytes can be sorted to high purity upon staining them with a dye that labels mitochondria. This permits the preparation of pure populations of cardiomyocytes differentiated from stem cells.
Mouse lines with inducible reprogramming factors expressed from a single genomic locus will allow reprogramming studies in multiple cell types and defined genetic backgrounds.
