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A spheroid assay that recapitulates angiogenesis in vivo and a ring assay to measure lymphangiogenesis in vitro expand the toolbox of techniques to investigate these processes during development and tumor progression.
A high-throughput pipeline to engineer bacterial artificial chromosomes (BACs) expressing tagged genes of higher eukaryotes allows large-scale protein localization and interaction studies.
Microscopic resolution far beyond the diffraction limit is possible by localizing single molecules individually. This approach has now been demonstrated on living cells.
Advances in methods that allow targeted remote control of neuronal activity open new possibilities for investigating and manipulating the function of neuronal circuits in vivo.
Although Drosophila melanogaster offers a variety of refined genetic techniques, it has lagged behind other model organisms in the high-resolution genotyping arena. A newly developed set of tools addresses this deficiency and provides a very welcome addition to the fly geneticists' armory.
A single biomolecule carries information that becomes lost in an ensemble average. Methodological developments in imaging are now making it easier to access this hidden information in a live-cell context.
Methods that improve DNA synthesis with reduced error rate and those that facilitate cloning of large DNA segments will be valuable in rebuilding genomes and provide a stepping stone on the way to genome design.