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A new method for expressing functional RNA molecules in vivo opens a route to easy RNA sample preparation, and establishes a set of tools for studies of RNA structure, interactions and function in vitro and in vivo.
A new mass spectrometry (MS) approach has been developed, allowing combinatorial analysis of histone H3.2 post-translational modifications that may provide the key to unlocking the histone code.
Although new super-resolution imaging techniques provide valuable biological insights, some applications, such as determining the organization of neural projections in the brain, are better served by comprehensive imaging of very large samples at lower resolution.
Researchers describe a general and highly efficient approach for incorporating a variety of unnatural amino acids into proteins at desired locations in mammalian cells.
Vectors allowing hydrophilic compounds to gain access to the cell interior are needed to reach new therapeutic targets. Transduction peptides have opened the way to this, but their chemical mimics may be of even greater interest.
Cellular imaging by fluorescence microscopy is becoming simultaneously higher-throughput and more quantitative as researchers develop integrated systems for image acquisition and analysis.
A method of time-resolved two-photon volume imaging with cellular resolution allows for the first time a comprehensive analysis of cortical microcircuits in vivo.
A new maximum likelihood–based algorithm allows cryo-EM structure determination of macromolecular complexes even when conformational heterogeneity is present.