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Cell-based reporters for dopamine and norepinephrine allow real-time measurements of these neurotransmitters in vivo with high specificity. They can address the temporal and spatial dynamics of volume neurotransmission in behaving animals.
Quantum dot–coated pipettes facilitate targeted electrophysiological recordings in deep brain tissue because they are readily visible owing to the strong two-photon fluorescence of the quantum dots.
Avoiding nonspecific binding is essential for performing fluorescence microscopy–based analyses of single molecules tethered to surfaces. A dichlorodimethylsilane–Tween-20–passivated surface provides a useful alternative to the standard poly(ethylene glycol) surface for single-molecule studies.
A method based on the Hadamard transform is shown to enable time-resolved X-ray crystallography measurements of protein dynamics at standard synchrotron sources.
Designer ribozymes show protein-responsive translational control and can be combined with transcriptional control elements to program complex gene circuits.
This paper reports an autofluorescent signal in cancer stem cells within epithelial tumors and describes its use as a marker to isolate and study these cells.
Communications between animals such as zebra finches can be discriminated with back-attached acceleration recorders. In contrast to microphones, these devices record the carrier's signals only, allowing a more precise analysis of individual vocalizations during social interactions.
This paper reports a combination of two small molecules for very efficient mouse cell reprogramming to induced pluripotency, achieving close to 100% reprogramming within a few days for some cell types.
The CONCOCT software performs unsupervised binning of metagenomic contigs across multiple samples to allow better genome reconstruction from microbial communities.
Quantum dots sequentially loaded into cells are used to generate barcodes that can identify thousands of individual cells within a population and that can be used to track cells over many hours.
A model that incorporates the quantitative relationship between microRNA and the expression of its target gene achieves predictable and robust genetic circuits.
LiFE is an algorithm that evaluates human connectome models derived from magnetic resonance imaging (MRI) and tractography methods. The algorithm achieves this goal by assessing the contribution of all the fiber tracts in a connectome to predict the measured MRI signal.
A set of targeted mass spectrometry assays for 'sentinel' proteins allows the activation of 188 yeast biological processes to be simultaneously monitored in 1 hour.
A microfluidic chip is used to construct a microarray of proteins, each labeled with a dockerin tag, for high-throughput single-molecule force spectroscopy experiments using a single cohesin-modified cantilever.