Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
An international blind study confirms that smFRET measurements on dynamic proteins are highly reproducible across instruments, analysis procedures and timescales, further highlighting the promise of smFRET for dynamic structural biology.
A modular architecture for managing and sharing electrophysiology, behavior, colony management and other data has been built to support individual laboratories or large consortia.
A self-inactivating variant of the CVS-N2c rabies virus enables both retrograde viral tracing and transcriptomic analyses, thereby allowing a combination of circuit mapping and molecular studies.
An unsupervised machine learning approach for anomaly detection, implemented as both a user-defined feature matrix and a self-supervised deep neural network, improves the mass sensitivity of iSCAT by a factor of 4 to below 10 kDa.
A three-photon miniature microscope with optimized light-collection efficiency facilitates imaging of neuronal activity throughout the cortex, as well as in the hippocampus, in freely moving mice.
Light-field microscopy is extended to mesoscale fields of view, allowing calcium imaging of thousands of neurons at a high frame rate and high spatial resolution.
Outbreak.info Research Library collects and integrates COVID-19 information from various repositories, enabling one-stop search for publications, clinical trials, datasets and other resources.
FD-DeepLoc uses field-dependent deep learning for precise localization of spatially variant point emitters over the full chip of a modern sCMOS camera, enabling fast and high-throughput volumetric localization microscopy.
The outbreak.info genomic reports provides comprehensive and detailed information about SARS-CoV-2 lineages and mutations worldwide, which facilitates near real-time genomic surveillance.
Bidirectional, cyanobacteriochrome-based light-inducible dimers (BICYCL)s enable optogenetic control of protein–protein interactions with green and red light, allowing multiplexing with existing blue light-controlled tools.
Spatial Omics DataBase (SODB) is a web-based platform for sharing and analyzing >25 types of spatial omics data. SODB promotes data reuse, offers novel visualization tools and can streamline development of omics analysis tools.
Adam optimization-based pointillism deconvolution (A-PoD) is a broadly applicable super-resolution deconvolution algorithm. A-PoD-coupled SRS microscopy reveals heterogeneous metabolic activity in subcellular structures like lipid droplets.
This analysis compares the performance of seven algorithms for cluster analysis of single-molecule localization microscopy data. The results provide a framework for comparing these types of methods and point users to the best tools.
EnzymeML is an XML-based markup language that enables FAIR (findable, accessible, interoperable and reusable) storage and exchange of enzymatic data such as reaction conditions, the time course of the substrate and the product, kinetic parameters and the kinetic model.