News & Comment

Live imaging enables temporal tracking of immune cell behavior.

Ultra-high-throughput sequence alignment enables identification of >130,000 novel RNA viruses.

Comprehensive modeling of cellular networks of cells with a minimal genome.

A metagenomic approach to identifying the sources of N⁶-methyldeoxyadenine (6mA) in eukaryotic DNA found no evidence of high 6mA abundances in sampled eukaryotes.

Highly multiplexed tissue imaging continues to show its power for biomedical discovery. In this issue, we publish tools and guidance for implementing this class of methods and reporting subsequent results.

Two groups report improved variants of the channelrhodopsins ChRmine and ChroME, respectively.

Hiking his way to a well-engineered translational future for tissue-based imaging.

The imminent release of tissue atlases combining multichannel microscopy with single-cell sequencing and other omics data from normal and diseased specimens creates an urgent need for data and metadata standards to guide data deposition, curation and release. We describe a Minimum Information about Highly Multiplexed Tissue Imaging (MITI) standard that applies best practices developed for genomics and for other microscopy data to highly multiplexed tissue images and traditional histology.

Labs are stacking techniques to disentangle the chemical influences of microbiomes.

Jellyfish are established as a model system for neuroscience.

Slide-DNA-seq enables profiling of spatially resolved mutations and clonal populations in intact tumor samples.

Clonal evolution of stem cells unveiled by modeling DNA methylation fluctuation.

Nature Methods is introducing a new article format: Registered Reports. We encourage all authors interested in submitting comparative analyses of the performance of established, related tools or methods to familiarize themselves with this alternative approach to peer review.

An imaging mass cytometry method reconstructs tissue microenvironments in 3D.

Researchers push the limits of confocal microscopy by combining multiple views, super-resolution and deep learning.

A bioengineer and world traveler with a systems approach to gene silencing.

Labs reaping information from single cells balance desirables with headaches such as data sparsity, cost and protocol surprises.

Lineage tracing methods help unravel complexities of cell state and differentiation programs.

Viral tools are a mainstay in mammalian neuroscience, but there is room for improvement.