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If you want to silence a single gene with relative ease, look no further than RNA interference (RNAi). Fast becoming the knockdown method of choice in many systems, RNAi reagents such as commercial small inhibitory RNAs (siRNAs) and specialized media are now widely available to streamline your work. Caitlin Smith sizes up some of the new tools available for RNAi.
Analysis of gene expression is critical to understanding the molecular underpinnings of normal and disease processes. Although in recent years the field has been flooded with microarray data, a multitude of non–array-based methods for studying the expression of genes are on the market. Laura Bonetta takes a look at them.