News & Comment

Cameras are a crucial part of microscopes and are also built into many kinds of instruments. To make their output comparable takes standards.

Imaging and microscopy technology advances in leaps and bounds. To address accumulated pain points, academics and companies are making headway on standards.

A newly described fluorescent protein, StayGold, is bright and extremely photostable, enabling extended time-lapse imaging.

TALE-fused deaminases enable C-to-T or A-to-G base editing in human mitochondria.

A coarse-grained model enables simulating droplet formation with low-complexity RNA sequences.

To recapitulate some of the complexities of the human physiology, engineered tissues can be linked by vascular flow in a multi-organ chip.

How to gauge academic culture and celebrate being an LGBT+ scientist.

Nature Methods is pleased to publish several papers presenting methods developed by members of the Telomere-to-Telomere (T2T) Consortium, which facilitated the generation and analysis of the first complete human genome.

A chemical cocktail reprograms human somatic cells into pluripotent stem cells.

The release of the first telomere-to-telomere (T2T) human genome sequence marks a milestone for human genomics research and holds promise of complete genomes for evolutionary genomic studies. Here we describe the advances that this new human genome assembly represents and explore the potential insights that the complete genome sequence could bring to evolutionary genomics. We also discuss the potential challenges to be faced in applying this new sequencing strategy to a broad spectrum of extant species.

Widespread adoption of new embryo models hinges on how faithfully they mirror real embryos.

MicroED for structure determination without a model and with heavy metal guitar riffs.

Cell-free DNA ‘fragmentomics’ empowers cancer detection and classification.

B_net provides a measure of radiation damage suffered by protein crystals during X-ray crystallography.

A genetic tracing approach follows the division history of cells in vivo.

It’s been a busy start to 2022 in the editorial offices of Nature Methods. We summarize several developments here: new content types, editorial initiatives, travel and outreach, and recent Focus issues.

Perturb-map combines multiplex imaging and spatial transcriptomics to dissect complex biological functions from CRISPR screens in tumor tissues.

The MINI2P is a two-photon miniscope that enables robust calcium imaging during mouse behavior.

Securing biodiversity takes many measures, including the involvement of Indigenous peoples.