News & Comment

Could the latest high-throughput technologies propel chemical genomics screens forward in academic settings? After 18 months of careful design and planning, scientists at the Broad Institute's chemical biology platform are about to flip the switches and find out.

Using chemically assembled ubiquitylated histone H2B, researchers demonstrate that direct cross-talk results in methylation of a lysine on another histone.

By engineering magnetic microstructures, researchers demonstrate the potential for multiplexed MRI.

A new protein tag simplifies labeling and visualization of newly synthesized target proteins in tissue and whole animals.

Researchers demonstrate a method for observing intact membrane protein complexes by mass spectrometry.

Next-generation sequencing–based studies locate nucleosomes at high resolution throughout several genomes.

Ongoing efforts show promise in replacing reprogramming factors with small molecules for making induced pluripotent stem cells.

The use of organized competition to evaluate algorithm performance would be very beneficial for small communities, not just large ones.

Mass spectrometry instrumentation has made strides in recent years in terms of dynamic range and sensitivity, putting researchers in a better position to use the technology to tackle the challenges of disease biomarker discovery and validation.

A high-resolution interactome map that describes how proteins interact in living yeast cells is an invaluable reference for the research community.

Tiny droplets of water in oil can serve as miniature culture vessels for living single cells and multicellular organisms.

Recently discovered electrophilic probes open the door to activity-based protein profiling (ABPP) studies of a broader range of proteins.

With access to high-throughput technologies, researchers struggle to store their raw data. Many just give up.

Zebrafish researchers rejoice! Reverse genetics is now on the menu, thanks to zinc-finger nucleases.

In designing microscopy software to take advantage of better hardware, developers are facing challenges of accessibility, functionality and usability.