Articles in 2010

Screening reveals a chemical activator that triggers apoptosis by locking inactive but dynamic proenzymes into a more active state, suggesting a promising strategy for targeting proteases.

A new technique finds genomic subpopulations to indicate cancer progression.

High-throughput saturation mutagenesis determines the contribution of each base in a core promoter to overall promoter strength.

Cardiomyocytes can be sorted to high purity upon staining them with a dye that labels mitochondria. This permits the preparation of pure populations of cardiomyocytes differentiated from stem cells.

Supercharged SRM: synthetic peptides bring high-throughput assays to targeted proteomics.

A miniature head-mounted two-photon microscope small enough for a rat to carry allows researchers to visualize neuronal signaling while the animal freely interacts with its environment.

Mouse lines with inducible reprogramming factors expressed from a single genomic locus will allow reprogramming studies in multiple cell types and defined genetic backgrounds.

Rapid progress with induced pluripotent stem cells is bringing scientists closer to understanding their strengths and weaknesses as embryonic stem cell stand-ins.