Method to Watch

Method development is indispensable for obtaining complete genomes, and deciphering them.

High-throughput and ultrasensitive mass spectrometry–based approaches are gaining ground in subcellular compositional analysis.

Probing spatially organized DNA and its interacting elements in single cells will deepen our understanding of cell-type-specific gene regulation.

Emerging algorithms are extracting information about macromolecular motions from cryo-EM data.

Glycoproteomics is coming of age, thanks to advances in instrumentation, experimental methodologies and computational search algorithms.

Organoids generated by spatially organizing multiple cell types, called assembloids, will enable deeper insights into tissue function.

Computational approaches help us explore complexities of the T cell receptor repertoire.

Method development pushes the limit of completeness of genome sequences.

Single-objective light sheet fluorescence microscopes are driving innovation in volumetric imaging.

Prime editors enable different types of small mutations to be introduced into genomes.

Researchers are putting new spins on familiar dyes and showing their versatility for labeling living systems.

Behavioral analysis has come a long way from tedious manual annotation, and further strides in automation are expected.