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Antibodies, the molecular workhorses of protein research, have traditionally been one of the most difficult reagents to procure. Using innovative new technologies, though, a burgeoning antibody production industry is turning these molecules into commodities.
A combination of scattering interferometry and single-molecule fluorescence microscopy allows visualization of both the position and orientation of single Simian virus 40 particles on lipid bilayers and provides evidence of viral interaction with receptors in membrane nanodomains.
A combination of forward and reverse two hybrid screening allows systematic identification of 'edgetic' or edge-specific alleles, which encode proteins that have lost a single physical interaction but for which other interactions remain unperturbed.
Glycan structure, attachment site and the glycoprotein from which it came can be identified with a method to enrich for glycoproteins from complex biological samples, digest them on a bead and release the glycopeptides for mass spectrometry analysis.
A cocktail of three small molecules improves the efficiency of reprogramming human fibroblasts to induced pluripotent stem cells and allows survival of the cells after trypsinization.
Protein complexes can be detected, counted and localized within the bacterium Leptospira interrogans by combining quantitative mass spectrometry–based proteomics analysis with cryo-electron tomography, with the aid of an improved template-matching method.