Research Highlights

Researchers optimize stimulated Raman scattering microscopy and combine it with a new panel of Raman-active dyes to enable 24-color bioimaging.

A chemical combination enables culture of pluripotent cells.

A spot of CRISPR protein on paper provides a powerful diagnostic assay.

A proximity labeling technique yields new insights into GPCR signaling.

A photodissociable dimer of the Dronpa fluorescent protein can cage kinases, making these important signal transducers controllable by light.

A FRET sensor enables quantitative characterization of electrostatic potential of membranes in living cells.

Proteome thermal stability is probed using limited proteolysis and mass spectrometry.

An iterative clustering approach finds the few genes that mark discrete cell states and their transitions during early mouse development.

In vitro culture of mouse embryonic and extra-embryonic stem cells recapitulates embryogenesis.

Thin slices through nuclei provide an unbiased view of the complex 3D organization of mammalian genomes.

Cryptic, widespread DNA damage is commonly interpreted as sequence variation.

A new approach measures nanoscale distances based on magnetic resonance tuning.

Bessel focus scanning and stereoscopy speed up volumetric brain imaging.

Trans-synaptic tracing that starts from a single neuron provides a detailed view of that neuron's inputs.

Cas13b relies on activator and repressor proteins to regulate RNA cleavage.

Low-energy holography enables imaging single proteins and protein complexes.

Two groups use cerebral organoids to model brain development and disease.

Light- or drug-dependent switches enable precise control over signaling pathways in living cells.

MINFLUX nanoscopy can obtain 1-nm localization precision with orders of magnitude fewer emitted photons.

Researchers have engineered a protease specific for a post-translational modification.