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Craspase is a new CRISPR tool that cleaves protein instead of DNA, and can be switched off — which makes it a potentially safer option than conventional CRISPR in the therapeutic setting.
Clinical research often excludes people with disabilities who have impaired decisional capacity, but they can be included through supported decision-making, where their decisions can be assisted by designated supporters of their choosing. This will promote equitable access to research.
Most health systems struggled to obtain and analyze real-time data during the COVID-19 pandemic, but places that succeeded can be studied to provide a model for data-enabled responses to future epidemics and pandemics.
Nature Medicine explores the latest translational and clinical research news, with an analysis of Intellia and Regeneron’s gene-editing treatment, which reduced levels of transthyretin in patients.
In this issue, Nature Medicine presents the Burden of Proof studies led by the Institute for Health Metrics and Evaluation, which quantitatively evaluate the strength of evidence of risk–outcome relationships to better inform effective clinical and policy recommendations.
The Global Burden of Disease provides essential data for evidence-based healthcare, but could be improved by investment in health data systems in low- and middle-income countries
Fungal communities in tumors are associated with clinical outcomes and may have diagnostic or prognostic utility — but whether they have a causative role remains to be seen.
Use of AI-driven care for patients with type 1 diabetes has freed up clinicians’ time to focus on patients’ quality of life and provide more empathic, patient-centered care.
Dogs develop diseases similar to those of humans, and their inbred genetics makes them a useful model for disease biology, allowing the development of new therapies for veterinary and human use.