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Comprehensive analysis of lung mononuclear phagocytes reveals four subsets with distinct basal transcriptomic and epigenomic landscapes and differing responses to inflammatory stimuli.
A T cell recognizing the MHC class I–related molecule MR1, expressed by a wide range of cancer cell types, might have great potential for adoptive cell therapy in cancer.
The fourth Innate Immune Memory meeting was held in the historic city of Nijmegen, in the eastern-central part of the Netherlands, to discuss the basic and translational aspects of innate immune memory, popularly known as ‘trained immunity’.
Group 3 innate lymphoid cells (ILC3s) are critical for maintaining gut epithelial integrity and tissue repair. Recent research identifies mechanisms by which circadian machinery and feeding behavior regulate enteric ILC3s to maintain gut homeostasis.
