Reviews & Analysis

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  • Dendritic cells have the unique capacity of processing soluble exogenous proteins for presentation to killer T lymphocytes. Now Cresswell and associates show that this is possible because pinocytosed material gains access to the perinuclear endoplasmic reticulum of dendritic cells.

    • Loredana Saveanu
    • Peter van Endert
    News & Views
  • The signaling pathways distinguishing positive and negative thymic selection are critical for establishing T cell immunity and tolerance. The kinase MINK might be an important component that differentiates these two events.

    • Ed Palmer
    News & Views
  • When confronted with a pathogen, the immune system must develop the appropriate type of immune response. Recent work provides new insight into how regulated gene activation and silencing occurs in helper T cells.

    • Federica Sallusto
    • Steven L Reiner
    News & Views
  • Human skin is surprisingly resistant to colonization by Escherichia coli, a prevalent commensal bacterium of the gut flora. An 11-kDa Zn2+-binding protein, psoriasin, is identified as the principal E. coli–bactericidal factor present at the surface of human skin.

    • Charles L Bevins
    News & Views
  • The fourth EMBO workshop on “Lymphocyte antigen receptor and coreceptor signaling” gathered immunologists to share key findings, new questions and emerging trends in the field of cell signaling.

    • Cosima T Baldari
    • Gary Koretzky
    • Oreste Acuto
    Meeting Report