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Data management has been neglected but should be made an integral activity in all research laboratories. Chaussabel and colleagues discuss how to implement this at the bench.
The Science Gallery, Trinity College Dublin, recently held an exhibition called “INFECTIOUS: STAY AWAY” that used art to illustrate infection and immunity. Luke O'Neill talks to one of the artists, Gordana Novakovic, about her involvement in this project.
The authors recount their discovery of how pathogen-induced interleukin 12 production leads to TH1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of TH1 cells.
By identifying gene products whose knockdown is associated with phenotypic changes, large-scale RNA-mediated interference screens have demonstrated previously unknown components of biological pathways. This commentary provides general guidelines for using such screens to answer questions of immunological interest.
The US National Institute of Allergy and Infectious Diseases convened a workshop of malaria investigators and immunologists to foster collaborations and attract more immunologists into malaria research. Discussions highlighted research gaps and underscored the incomplete understanding of basic immune mechanisms that contribute to the pathogenesis of or protection against malaria.