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Cell and tissue polarity mechanisms organize functional domains at the surface of many cells. Here, authors reveal that a Wnt-Ror-Dvl signalling cascade forms planar-polarized membrane compartments in C. elegans muscle cells.
Mechanical allodynia can be socially transferred. Here, authors show that a small population of mice exhibit resilience to socially transferred allodynia, an active process mediated by ventral tegmental area glutamatergic circuits.
Faithful transfer of quantum states between different parts of a single complex quantum circuit will become more and more important as quantum computing devices grow in size. Here, the authors transfer single-qubit excitations, two-qubit entangled states, and two excitations across a 6 × 6 superconducting qubit device.
Here, the authors identify 200 Varicella-Zoster Virus (VZV) circRNAs, confirmed in HZ patient tissues. Numerous latency-associated transcripts (VLTs)-like circRNAs (circVLTslytic) were found with multiple exons and splice donor sequences that influence formation. circVLTslytic RNAs are non-essential for VZV replication but affect ACV sensitivity.
The bidirectional halide and silver migration cause irreversible chemical corrosion to electrodes and perovskite layer. Here, the authors employ 4,4’-dicyano-2,2’-bipyridine in the electron transport layer to coordinate silver and iodide, realizing stable solar cells with efficiency over 26%.
Sustainable chemistry can benefit from biocatalysis, but a high diversity of enzymes is needed. Here, the authors screen billions of protein sequences to provide an overview of the native amine dehydrogenase family for amine synthesis.
Chlamydia trachomatis invades host epithelial cells using the two effectors TarP and TmeA. Here, Romero et al find that host GTPase dynamin 2 is also recruited to invasion sites where it is required for uptake, and is regulated by TarP and TmeA.
Histidine kinases form part of bacterial two-component signaling systems (TCS). By modulating the balance between antagonistic kinase and phosphatase activities, the authors reprogram output and sensitivity of light-responsive TCSs, thus generating tools for gene-expression control by red light.
Membrane proteins play essential roles in biological processes but are very difficult to study due to their hydrophobic nature. Here, the authors apply the QTY code, a method for designing water soluble membrane proteins, to histidine kinase CpxA to render it completely water-soluble and preserve the native molecular function.
In this target trial emulation study, the authors evaluate effectiveness of nirmatrelvir/ritonavir in non-hospitalized paediatric patients aged 12–17 years with SARS-CoV-2 Omicron infection and show reduced risks of 28 day all-cause mortality or hospitalization associated with the treatment.
The preparation of C − N axially chiral compounds, a class of privileged scaffolds in pharmaceuticals, advanced materials and organic synthesis, has recently attracted significant interest. Herein the authors report a chiral dinitrogen ligand promoted asymmetric Catellani reaction for the synthesis of C–N axially chiral scaffolds.
The robust anion framework of ionic nanocrystals impedes shape change by cation exchange. Here, the authors report an anisotropic, regenerative transformation of Cu1.8S nanoplates during cation exchange.
Synthetic biology applications require finely tuned gene expression, often mediated by synthetic transcription factors. Here the authors validate two plant-derived proteins, FHY1 and FHL, acting as transactivators in mammalian cells for orthogonal, modular, and tunable control of gene transcription by forming a photosensing transcriptional regulation complex with PhyA.
While synthetic active matter research has concentrated on developing point-like, interacting entities, designing freely jointed active assemblies from autonomously powered components has remained a challenge. Here, the authors introduce freely jointed active polymers created from self-propelled droplets, uncovering emergent rigidity and propulsion, thereby advancing towards self-morphic synthetic materials.
Informal transportation services constitute the primary form of public transport in the Global South. Here, the authors analyze the structure of route networks in cities across the globe, showing how informal routes self-organize into consistent line services that often outperform centralized services in the Global North, exhibiting fewer detours and comparable interconnectivity.
By performing a tissue-specific transcriptome analysis, Zhang et al. show how age-related loss of germline stem/progenitor cells in C. elegans is regulated by a signal produced by non-niche cells within the same organ system.
To identify intracellular dynamics at the single-cell level, authors develop a scalable method via a divide-and-conquer strategy and apply it to a yeast transcription system. The results underscore the heterogeneity in isogenic cells, which is validated by a noise-decomposition method.
Developing artificial leaves is crucial for advancing Net Zero Future, but most artificial leaves rely on the use of metal or semiconductors catalysts that usually have a lower catalytic activity and selectivity compared to biocatalysts. Here the AUs report Ecoleaf, a biodegradable artificial leaf that mimics the controlled expansion and contraction of stomata and enables enzymic CO2 conversion.
Biological computing is a promising field with potential applications in biosafety, environmental monitoring, and personalized medicine. Here the authors create bio-computers using engineered E. coli colonies that respond to chemical gradients, producing different logic functions depending on how they are spatially arranged.
The scalable fabrication of wide-bandgap perovskites in air remains challenging due to moisture-induced degradation of perovskites. Here, authors utilize low polarity and moderately volatile n-butanol to enhance film uniformity, achieving efficiency of 29.4% for double-sided textured tandem cells.