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RNA-based programmable DNA cleavage
Natural ribozymes can cleave RNA and single-stranded DNA (ssDNA) by transesterification or a blend of hydrolytic and transesterification reactions. Now, ribozymes have been discovered that catalyze the hydrolytic cleavage of ssDNA. Similar ribozymes could potentially replace large, immunogenic, protein-based nucleases in gene therapies.
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Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli
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The β-subunit of tryptophan synthase is a latent tyrosine synthase
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PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein
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Versatility of biological non-heme Fe(II) centers in oxygen activation reactions