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Neoantigen-targeting vaccines are a feasible therapy for tumours with a low mutation burden and immunologically ‘cold’ tumour microenvironment, as neoantigen-specific T cells from the peripheral blood migrate into intracranial glioblastoma, thereby altering the immune milieu of the glioblastoma.
Quantized conductivity is observed along a Weyl orbit in wedge-shaped samples of the topological semimetal Cd3As2, providing evidence of the quantum Hall effect in three dimensions.
The nonlinear Hall effect is observed in bilayer WTe2 in the absence of a magnetic field, providing a direct measure of the dipole moment of the Berry curvature.
Archived vials of cadaveric human growth hormone contain substantial levels of amyloid-β (Aβ) peptides and can seed Aβ plaques in susceptible mice, suggesting that this material could have transmitted Aβ pathology to humans.
Photochemical deracemization through irradiation with visible light in the presence of a chiral sensitizer enables the direct formation of single enantiomers from a racemic mixture of the same compound.
Despite inter-model differences in predicting the details of the eastern Pacific El Niño, a robust increase in the corresponding sea surface temperature variability under greenhouse warming is found across models.
A subnanometre-resolution cryo-electron microscopy structure of the Rh5–CyRPA–Ripr complex of Plasmodium falciparum provides insights into how this ligand interacts with the receptor basigin in erythrocyte hosts.
A fully connected quantum network is demonstrated in which one source of entangled photons distributes quantum states to four users, with the potential for many more users to be added.
Cryo-electron microscopy structures of connexin channels composed of connexin 46 and connexin 50 in an open-state reveal features that govern permselectivity and the location of mutated residues linked to herediatry cataracts.
Topological nanoelectromechanical metamaterials are realized at the micrometre scale, using silicon nitride nanomembranes, opening the way for on-chip integrated acoustic components in high-frequency signal-processing applications.
Evaluation of the efficiency of land-use changes and their effect on global carbon storage shows that several land-use and consumption choices relevant to climate policy have greater implications than previously thought.
The cryo-electron microscopy structure of the gp120 component of the HIV-1 envelope glycoprotein, in complex with the primary receptor CD4 and coreceptor CCR5, provides insight into the cell-entry mechanism of HIV-1.
Atrial natriuretic peptide, an anti-inflammatory protein, can protect against cytokine release syndrome induced by therapeutic agents such as tumour-targeting bacteria and CAR-T cells by blocking catecholamine synthesis by macrophages.
In mouse macrophages, a range of short and non-ATG-initiated open reading frames that can generate proteins are identified, one of which is shown to be essential for host immunity to enteric mucosal infection and inflammation.
A method for encoding the non-canonical amino acid 2,3-diaminopropionate into proteins allows key acyl intermediates in the biosynthesis of valinomycin to be trapped, providing insight into the oligomerization and cyclization reactions involved.
Direct observation of incommensurate spin correlations in doped and spin-imbalanced Hubbard chains confirms two fundamental predictions for Luttinger liquids and shows that such correlations are suppressed by interchain coupling.
Misexpression of the sperm-cell-expressed transcription factor BABY BOOM1 in the rice egg cell induces embryo development without fertilization, establishing the feasibility of asexual reproduction in crops and potentially enabling the clonal propagation of hybrids through seeds.
An electrically controlled phase transition from topological insulator to conventional insulator in ultrathin films of the topological Dirac semimetal, Na3Bi.
In mice, the ablation of spinal neurons that co-express TAC1 and LBX1 leads to the loss of coping responses to sustained pain without affecting reflexive defensive reactions to external threats.