Research articles

Two signals identified in short gamma-ray bursts from archival Burst and Transient Source Experiment data show kilohertz quasiperiodic oscillations, implying the ringing of a hypermassive neutron star before collapsing to a black hole.

The medium-resolution transmission spectrum of the exoplanet WASP-39b, described using observations from the Near Infrared Spectrograph G395H grating aboard JWST, shows significant absorption from CO₂ and H₂O and detection of SO₂.

The transmission spectrum of the exoplanet WASP-39b is obtained using observations from the Single-Object Slitless Spectroscopy mode of the Near Infrared Imager and Slitless Spectrograph instrument aboard the JWST.

A broad-wavelength 0.5–5.5 µm atmospheric transmission spectrum of WASP-39b, a 1,200 K, roughly Saturn-mass, Jupiter-radius exoplanet, demonstrates JWST’s sensitivity to a rich diversity of exoplanet compositions and chemical processes.

An electrochemical strategy is described in which the direct carboxylation of pyridines and related N-heteroarenes with CO₂ shows divergent site selectivity depending on the type of reactor used.

A ‘bottom-up’ approach for calculating the rate of organic carbon burial in the global ocean shows larger variability than has been previously estimated, suggesting that the organic carbon cycle acted as positive feedback of past global warming.

Cryo-electron microscopy structures of Staphylococcus aureus BlaR1 reveal dynamic signalling states regulating broad spectrum β-lactam antibiotic resistance through cleavage of the transcriptional repressor BlaI and induced expression of the β-lactamase blaZ and the β-lactam-resistant cell-wall transpeptidase mecA.

Immune responses to influenza vaccination are affected by previous mild COVID-19 in a sex-dimorphic manner.

The authors investigate chemical anomalies in superdeep diamond inclusions, leading them to suggest that there is an extremely variable redox environment in the deep mantle.

A decline in disruptive science and technology over time is reported, representing a substantive shift in science and technology, which is attributed in part to the reliance on a narrower set of existing knowledge.

An in vitro system that recapitulates temporal characteristics of embryonic development demonstrates that the different rates of mouse and human embryonic development stem from differences in metabolic rates and—further downstream—the global rate of protein synthesis.

Analysis of behaviour, physiology, anatomy and connectomics in Drosophila shows how direction-specific visual information is transformed onto downstream premotor networks and converted into appropriate motor responses.

Structural analysis of Cas12a2, a CRISPR-associated nuclease that nonspecifically cleaves ssRNA, ssDNA and dsDNA, reveals a complete activation pathway involved in the abortive infection system protecting cells against invasion.

Using cryo-electron microscopy, structural and mechanistic insights into how the METTL1–WDR4 complex catalyses methylation of tRNAs are shown.

A van der Waals crystal, niobium oxide dichloride, with vanishing interlayer electronic coupling and considerable monolayer-like excitonic behaviour in the bulk, as well as strong and scalable second-order optical nonlinearity, is discovered, which enables a high-performance quantum light source.

HIV-infected memory CD4 T cells under antiretroviral therapy are a distinctive population of cells with transcriptomic patterns that favour HIV silencing, cell survival and cell proliferation.

Single-molecule calibrated live microscopy and computational modelling have revealed that human nuclear pore complex assembly takes different pathways during the exit from mitosis and during nuclear growth in interphase.

A study of intracluster light (ICL) in ten high-redshift galaxy clusters finds evidence that gradual stripping may not be the dominant mechanism of ICL formation, but may occur alongside the formation and growth of the brightest cluster galaxies, and/or accretion of preprocessed stars.

A dataset of 3D images from more than 200,000 human induced pluripotent stem cells is used to develop a framework to analyse cell shape and the location and organization of major intracellular structures.

RNA targeting by the Sulfuricurvum type V single-effector nuclease SuCas12a2 drives abortive infection through non-specific cleavage of double-stranded DNA—after recognition of an RNA target through an activating protospacer-flanking sequence, SuCas12a2 efficiently degrades ssRNA, ssDNA and dsDNA.