Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Many glaciers and ice shelves in the West Antarctic Ice Sheet are retreating or thinning rapidly, but the triggering mechanism has been unclear; now, the retreat of Pine Island Glacier is found to have begun in the 1940s following warming El Niño events in the Pacific Ocean, showing that glacial retreat can continue long after an initial push from the climate.
Inhibition of mechanistic target of rapamycin (mTOR) suspends mouse blastocyst development and the cells remain ‘paused’ in a reversible pluripotent state, allowing prolonged culture.
A combination of high humidity and bacterial effectors, such as Pseudomonas syringae HopM1, creates an aqueous environment in the apoplast of immunodeficient Arabidopsis thaliana that allows non-pathogenic P. syringae strains to become virulent pathogens.
Socially synchronized rhythms in shorebirds were assessed during biparental incubation under natural circumstances and were exceptionally diverse, often not following the 24-h day, whereby risk of predation, not starvation, determined some of the variation in incubation rhythms.
A general strategy for producing solution-processed doped polymers with the extreme work functions that are required to make good ohmic contacts to semiconductors is demonstrated in high-performance light-emitting diodes, transistors and solar cells.
A new system, termed MEMOIR, allows cells to record lineage and gene expression history within their own genome in a format that can be read out in single cells in situ.
There is an abrupt transition from alkaline to acid soil pH when mean annual precipitation exceeds mean annual potential evapotranspiration, demonstrating that climate creates a nonlinear pattern in soil solution chemistry at the global scale.
Genomic and molecular analyses of Clunio marinus timing strains suggest that modulation of alternative splicing of Ca2+/calmodulin-dependent kinase II represents a mechanism for evolutionary adaptation of circadian timing.
The structures of three intermediate states of photosystem II, which is crucial for photosynthesis, have been solved at room temperature, shedding new light on this process.
MutS and MutL—the highly conserved core proteins responsible for the repair of mismatched DNA—form sequential stable sliding clamps that together modulate one-dimensional diffusion along the DNA and, with MutH, facilitate the search for a distant excision initiation site.
A thermodynamic model of fluid pH and its variability in Earth’s mantle and subducting crust highlights chemical feedbacks that connect deep Earth to surface processes.
To explain the position of the Sputnik Planitia basin on Pluto, the feature would need to have formed via impact and Pluto would need to have a subsurface ocean.
Drosophila have two pathways for PIWI-interacting RNA (piRNA) 3′-end formation—depending on which pathway is used, piRNA biogenesis is directed towards either cytoplasmic or nuclear PIWI protein effectors, which balances post-transcriptional versus transcriptional transposon silencing.
The authors have designed modular synthetic hydrogel networks for mouse and human intestinal stem cell cultures that support intestinal organoid formation.
A method for CRISPR-based genome editing that harnesses cellular non-homologous end joining activity to achieve targeted DNA knock-in in non-dividing tissues.
Introducing non-covalent crosslinking moieties to polymer semiconductors produces a stretchable and healable material suitable for wearable electronics.
The authors report a 2.6 Å resolution crystal structure of the human CB1 cannabinoid receptor trapped in the inactive conformation and bound to the antagonist taranabant.
The location of Sputnik Planitia on Pluto is shown to result from volatiles sequestered within the basin forcing the reorientation of the dwarf planet, as supported by the planet-wide fault network.
The structures of several states on the pathway of SelB-mediated delivery of selenocysteine-specific tRNA to the ribosome in Escherichia coli reveal the mechanism of UGA stop codon recoding to selenocysteine and show how codon recognition triggers activation of translational GTPases.