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Single-cell analyses of skin samples from patients with vitiligo and functional genetic experiments in vitiligo mouse models show that distinct fibroblast subsets drive the organ level lesion patterns in this autoimmune disease.
A technique using barcoded beads for DNA sequencing within tissue sections enables spatial resolution of tumour clonal heterogeneity and can be multiplexed with other analytical techniques for analysis of complex cellular phenotypes.
Specific neurons in the fan-shaped body of the Drosophila brain convert translational information in relation to the fly’s body to externally referenced coordinates for navigation.
The krypton isotopic pattern of Earth’s deep mantle indicates that volatile-rich material from the outer Solar System was delivered early in Earth’s accretion history.
A strong association has been found between three regions of the Plasmodium falciparum genome and sickle haemoglobin in children with severe malaria, suggesting parasites have adapted to overcome natural host immunity.
A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.
A massive field study whereby many different treatments are tested synchronously in one large sample using a common objectively measured outcome, termed a megastudy, was performed to examine the ability of interventions to increase gym attendance by American adults.
Crystal structures of the σ2 receptor are determined and used to perform a docking screen of nearly 500 million molecules, identifying σ2-selective ligands and providing insight into the role of σ2 in neuropathic pain.
Cryo-electron microscopy of aggregated TDP-43 from postmortem brain tissue of individuals who had ALS with FTLD reveals a filament structure with distinct features to other neuropathological protein filaments, such as those of tau and α-synuclein.
A study of mice exposed to cigarette smoke suggests that smoking-cessation-induced weight gain is associated with a dysbiotic state that is driven by smoking-related metabolites.
Cryo-electron microscopy structures of the photosystem I–NADH dehydrogenase-like supercomplex in barley provide structural details to elucidate the functions and regulation of photosystem I-dependent cyclic electron transport in chloroplasts.
A stretchable anode, cathode, semiconductor and current collector have been developed to create stretchable diodes that can operate at megahertz frequencies for use in wirelessly operated, skin-like wearable electronics.
Cryo-electron microscopy structures of the sodium–glucose cotransporter SGLT1 and a related transporter SMCT1 define the architecture of this protein family and provide insights into substrate binding and transport function.
Plasma from voluntarily running mice reduces baseline expression of neuroinflammatory genes and experimentally induced brain inflammation when infused into sedentary mice.
A direct imaging study demonstrates the existence of a giant planet in a wide orbit around the high-mass b Centauri binary system, and uses measurements of the orbital properties to discuss its formation mechanism.
An emergent constraint combining biosphere models and carbon budget estimates suggests that the increase in the global terrestrial carbon sink is caused largely by a CO2-induced increase in photosynthesis.