Research articles

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  • Neuropixels recordings from the language-dominant prefrontal cortex reveal a structured organization of planned words, an encoding cascade of phonetic representations by prefrontal neurons in humans and a cellular process that could support the production of speech.

    • Arjun R. Khanna
    • William Muñoz
    • Ziv M. Williams
    ArticleOpen Access
  • Serial femtosecond crystallography reveals the structural dynamics of photosystem II during the S-state transitions that produce dioxygen, providing insight into electron transfer, water insertion, proton release and O–O bond formation on sub-microsecond timescales.

    • Hongjie Li
    • Yoshiki Nakajima
    • Jian-Ren Shen
    ArticleOpen Access
  • Through archaeological excavation, morphological and proteomic taxonomic identification, mitochondrial DNA analysis and direct radiocarbon dating of human remains, a study reports the presence of Homo sapiens in Germany north of the Alps more than 45,000 years ago.

    • Dorothea Mylopotamitaki
    • Marcel Weiss
    • Jean-Jacques Hublin
    ArticleOpen Access
  • A computational model generates conformational ensembles of 28,058 intrinsically disordered proteins and regions (IDRs) in the human proteome and sheds light on the relationship between sequence, conformational properties and functions of IDRs.

    • Giulio Tesei
    • Anna Ida Trolle
    • Kresten Lindorff-Larsen
    Article
  • Sea otters recolonizing an estuary in California indirectly reduce erosion by reducing burrowing crab abundance, suggesting that restoring predators could be a key mechanism to improve the stability of coastal wetlands and other ecosystems.

    • Brent B. Hughes
    • Kathryn M. Beheshti
    • Brian R. Silliman
    Article
  • The E3 ligase SIFI is identified as a dedicated silencing factor of the integrated stress response, a finding that has implications for the development of therapeutics for neurodegenerative diseases caused by mitochondrial protein import stress.

    • Diane L. Haakonsen
    • Michael Heider
    • Michael Rapé
    ArticleOpen Access
  • We develop a proton-exchange membrane system that reduces CO2 to formic acid at a catalyst that is derived from waste lead–acid batteries and in which a lattice carbon activation mechanism contributes.

    • Wensheng Fang
    • Wei Guo
    • Bao Yu Xia
    Article
  • Quantitative time-resolved microscopy analysis of SHR and SCR dynamics in single cells of living Arabidopsis roots shows that these transcription factors coordinate formative and proliferative cell divisions early in the cell cycle.

    • Cara M. Winter
    • Pablo Szekely
    • Philip N. Benfey
    ArticleOpen Access
  • A study reports a combination of processing, optimization and low-damage deposition methods for the production of silicon heterojunction solar cells exhibiting flexibility and high performance.

    • Yang Li
    • Xiaoning Ru
    • Zongping Shao
    Article
  • 7-Dehydrocholesterol (7-DHC) is a natural anti-ferroptotic metabolite and pharmacological manipulation of 7-DHC levels shows promise as a therapeutic strategy for cancer and ischaemia–reperfusion injury.

    • Yaxu Li
    • Qiao Ran
    • Ping Wang
    Article
  • A mechanical design is developed for the fabrication of ultralong, fracture-free and perturbation-free semiconductor fibres to address the increasing demand for flexible and wearable optoelectronics.

    • Zhixun Wang
    • Zhe Wang
    • Lei Wei
    ArticleOpen Access
  • Ultracold polyatomic molecules can be created by electroassociation in a degenerate Fermi gas of microwave-dressed polar molecules through a field-linked resonance.

    • Xing-Yan Chen
    • Shrestha Biswas
    • Xin-Yu Luo
    ArticleOpen Access
  • We study the interplay between cohesin and replication by reconstituting a functional replisome using purified proteins, showing how cohesin initially responds to replication and providing a molecular model for the establishment of sister chromatid cohesion.

    • Yasuto Murayama
    • Shizuko Endo
    • Hiroyuki Araki
    Article
  • Reconstruction of four Treponema pallidum genomes associated with human remains from around 2,000 years ago suggests that T. pallidum existed in the Americas and diverged to its modern subspecies before the fifteenth century European contact with the Americas.

    • Kerttu Majander
    • Marta Pla-Díaz
    • Verena J. Schuenemann
    ArticleOpen Access