Research articles

An analysis of the orbital motion of Saturn’s moon Mimas shows that a recently formed global subsurface ocean lies beneath its cratered icy shell and that this ocean is probably still evolving.

Spatial and single-cell transcriptomic analyses of the mouse basolateral amygdala reveal transcriptomic signatures, spatial resolution and interactions of cells that constitute the memory engram, including crucial neuron–astrocyte interactions.

A spin–orbital- and angular-momentum-sensitive methodology used to study Sr₂RuO₄ reveals subtle spectroscopic signatures that are consistent with the formation of spin–orbital chiral currents at the surface of the material.

Translation actively dislodges stalled transcription elongation complexes (ECs) from damaged DNA, which enables lesion repair and restoration of transcription activity, and coupled ribosomes discriminate between active ECs and stalled ECs, ensuring destruction of only the latter.

Calendar ageing of lithium metal batteries in the discharged state improves capacity retention through isolated lithium recovery, which is in contrast with the capacity degradation observed during charged state calendar ageing.

Acyltransferase activity of the enzyme bile salt hydrolase is identified and shown to mediate microbial bile acid conjugation, diversifying the bile acid pool and expanding their role in gut physiology.

This study describes experiments with ultracold lithium Fermi gases in which many-body pairing leads to the emergence of a pseudogap, and it confirms theoretical predictions relevant to cuprate superconductivity.

Cryo-electron microscopy structures of the human calcium-sensing receptor in complex with G_i and G_q proteins reveal how this receptor activates distinct G protein subtypes and how its function is modulated by a variety of ligands.

We find that bile salt hydrolase N-acyltransferase activity can form bacterial bile acid amidates that are positively correlated with the colonization of gut bacteria that assist in the regulation of the bile acid metabolic network.

Here we show how PFL2 and PFL3 neurons in the Drosophila brain compare a representation of direction with internal spatial goals, both anchored in world-centric coordinates, and produce body-centric steering commands that act to correct deviations from the goal direction. 

The Kupffer cell lineage-determining factor ID3 selectively endows macrophages with the ability to phagocytose live tumour cells and orchestrate the recruitment, proliferation and activation of natural killer and CD8⁺ T lymphoid effector cells to restrict the growth of a variety of tumours.

Variant-to-gene-to-program is a new approach to building maps of genome function to link risk variants to disease genes and to convergent signalling pathways in an unbiased manner; its strength is demonstrated in coronary artery disease.

Cryo-electron microscopy structures of intermediates formed during the degradation of the 30S ribosomal unit shed light on how the 3′ to 5′ exonuclease ribonuclease R controls the ribosomal degradation process.

Studies in mice show that observational fear learning is encoded by neurons in the dorsomedial prefrontal cortex in a manner that is distinct from the encoding of fear learned by direct experience.

We introduce a method for the direct 1,3-difunctionalization of alkenes, based on a concept termed ‘charge relocation’, which enables stereodivergent access to 1,3-difunctionalized products of either syn- or anti-configuration from unactivated alkenes.

We investigate the mechanism underlying the sulfur reduction reaction that plays a central role in high-capacity lithium sulfur batteries, highlighting the electrocatalytic approach as a promising strategy for tackling the fundamental challenges associated with these batteries.

A machine learning model for generating crop-specific and spatially explicit NH₃ emission factors globally shows that global NH₃ emissions in 2018 were lower than previous estimates that did not fully consider fertilizer management practices.

Proferroptotic activity of 7-dehydrocholesterol reductase is shown along with an unexpected prosurvival function of its substrate, 7-dehydrocholesterol, indicating a cell-intrinsic mechanism that could be used by cancer cells to protect phospholipids from oxidative damage and escape ferroptosis.

The slow maturation of human neurons is regulated by epigenetic modification in nascent neurons, mediated by EZH2, EHMT1, EHMT2 and DOT1L.

Structural changes mediated by advanced glycation end-products enhance extracellular matrix viscoelasticity, and that viscoelasticity can promote cancer progression in vivo, independent of stiffness.