Research articles

A neural stem cell culture system derived from induced pluripotent stem cells forms a network of synaptically connected and electrophysiologically active neurons that were used as a model system to identify a mechanism of TDP-43-induced neurodegeneration.

Using photoemission spectroscopy and ab initio calculations, evidence is given of two distinct unconventional mechanisms of lifted Kramers spin degeneracy generated by the altermagnetic phase of centrosymmetric MnTe with vanishing net magnetization.

The stacking of freestanding ferroelectric perovskite layers with controlled twist angles results in a peculiar pattern of polarization vortices and antivortices that emerges from the flexoelectric coupling of polarization to strain gradients.

A room-temperature demonstration of optomechanical squeezing of light and measurement of mechanical motion approaching the Heisenberg limit using a phononic-engineered membrane-in-the-middle cavity with ultralow noise.

Single-cell transcriptome profiling of mouse embryos and newborn pups is combined with previously published data to construct a tree of cell-type relationships tracing development from zygote to birth.

JWST/NIRSpec observations of Abell2744-QSO1 show a high black-hole-to-host mass ratio in the early Universe, which indicates that we are seeing the black hole in a phase of rapid growth, accreting at 30% of the Eddington limit.

A massive galaxy observed with the JWST indicates that the bulk of its stars formed within the first 500 million years of the Universe.

Conversion of rainforest to plantations in Sumatra leads to higher energetic losses in animal food webs aboveground than belowground, with the belowground energy being reallocated from diverse arthropod communities to invasive earthworms.

SAFB proteins protect genome integrity by preventing retrotransposition of L1 elements yet maintaining splicing integrity, via prevention of the exonization of previously integrated transposable elements, a major constituent of human genes.

X-ray observations of two large glitches bracketing a fast radio burst in the active Galactic magnetar SGR 1935+2154 reveal a connection between rapid spin change and radiative behaviours of the magnetar.

A trapped-ion quantum processor is used to create ground-states and excitations of non-Abelian topological order on a kagome lattice of 27 qubits with high fidelity.

We use bimolecular homolytic substitution catalysis to sort an electrophilic radical and a nucleophilic radical across an unactivated alkene, accelerating access to pharmaceutically relevant C(sp³)-rich molecules and defining a mechanistic approach for alkene dialkylation.

Serum MMP8 is increased in stress-susceptible mice following chronic stress and leads to brain structure and behavioural changes in mice.

Arachnoid cuff exit points create openings in the arachnoid barrier enabling the drainage of cerebrospinal fluid and exchange of molecules and cells between the dura and the subarachnoid space, therefore physically connecting the brain and the dura.

A study examines the effects of mutations that occur naturally in T cell cancers, reporting that such mutations can potentially be exploited to increase the potency of T cell therapies.

Vectorial optoelectronic metasurfaces are described, showing that light pulses can be used to drive and direct local charge flows around symmetry-broken plasmonic nanostructures, leading to tunable responses in terahertz emission.

Contrary to expectations from pollen and dust records, Southern Hemisphere subtropical regions experienced the greatest climatic moisture during glacial periods of the Late Pleistocene, which may not have been an obstacle to movement and expansion of animals and plants.

We provide evidence for superconducting topological Fermi arcs in PbBi₂—a Weyl semimetal previously studied mostly for its bulk properties—from which Marjorama fermions could be derived for research in quantum computers.

In Drosophila, FC2 neurons signal a navigational goal, which is compared with the fly’s heading by PFL3 neurons to guide moment-to-moment steering.

A Ca–O₂ battery that relies on a highly reversible two-electron redox to form chemically reactive calcium peroxide as the discharge product is reported to be stable in air and rechargeable for 700 cycles at room temperature.