A GWAS finds genetic link in ABCC9 gene affecting vocal pitch in both Mandarin and Icelandic speakers, suggesting a shared genetic influence on human vocal systems across populations.

A study on global arthropod biodiversity dynamics reveals that beta-diversity increased with latitude, distance, and time. Species replacement and richness difference patterns vary across regions, supporting global biodiversity expectations.

Multiomic study reveals that tumor microenvironmental factors such as hypoxia influence intracellular infection of Fusobacterium nucleatum in colorectal cancer cells and provides clues to malignant transformation of infected cells.

Personalized brain activity models in Alzheimer’s disease detect synergistic amyloid-β and tau impacts on neuronal excitability values, which significantly predict brain atrophy, p-tau217 plasma concentrations, and cognitive deterioration.

A study found that circFOXP1 was highly expressed in gastric cancer (GC) and demonstrated that ALKBH5-mediated m6A modification of circFOXP1 promoted GC progression by regulating SOX4 expression and sponging miR-338-3p.

A high-resolution structure provides a mechanistic explanation to the synthetic selectivity of quinolone synthase (AmQNS) and possible consequences of functionally relevant residue mutations.

Using multi-isotope analysis of tooth enamel of reindeer, equids and mammoth from the archaeological sites of Königsaue and Breitenbach, the authors identify shifts in ranging behaviour of these hominin prey species during the Last Glacial Period in Central Germany.

EP4 receptor enhances OSCC cell migration through increased Ca²⁺ signaling, linking to CALML6 and the CaMKK2 pathway. This process promotes mitochondrial function and metastasis, with CaMKK2 emerging as a potential target for OSCC treatment.

This study shows that the soil microbial community and herbivory both influence the assembly of the plant-associated microbial communities, but their effects are generated through different mechanisms.

An orally available VHL-ERα PROTAC was developed that showed excellent degradation in vitro. When dosing in vivo, the degradation of ERα was lower than expected, due to competitive binding at the ERα binding site between the PROTAC and a linker metabolite.

This comment reports on work done at Harvard Medical School to identify areas for improvement in research rigor, reproducibility, and responsibility in pursuit of continued research excellence.

Documentation of women’s inclusion in Indian academia and conferences by BiasWatchIndia reveals the scale of underrepresentation of women across science, technology, engineering and mathematics.

In 2023, we conducted a virtual program to introduce early-career researchers to the fundamentals of academic journal editing. Here, we reflect on the mission of this program and its outcomes.

A comment article summarizing a range of research activities that contribute to understanding evolving Māori perspectives on Gene Editing and how they might contribute to future regulation.

Nanoparticle therapy continues to be an attractive avenue of targeted and personalised therapies. A molecular nano-conjugate developed by Zeng et al. effectively targets cancer cells and aids in their diagnosis, therapy, and also optimises innate immune responses.