The mechanisms responsible for replicative misincorporation of an adenine into DNA opposite 8-oxoguanine (8OG) remain obscure. A new study suggests that 8OG redistributes the balance between several mispair conformations, enabling the high rates of misincorporation of adenine paired with 8OG by DNA polymerases.
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Smirnov, S.L. DNA damage twists base choreography. Nat Chem Biol 19, 797–798 (2023). https://doi.org/10.1038/s41589-023-01315-4
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DOI: https://doi.org/10.1038/s41589-023-01315-4