Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communications Arising
  • Published:

Sampaolesi et al. reply

Nature volume 450, pages E23–E25 (2007)Cite this article

Abstract

Replying to: A. H. Bretag Nature 450, 10.1038/nature06437 (2007)

Bretag1 questions our finding2 that “dogs benefited from mesoangioblast treatment”. We believe that this scepticism is not supported by careful examination of our data2.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Expression of wild-type dystrophin in dogs transplanted with wild-type mesoangioblasts.

Similar content being viewed by others

References

  1. Bretag, A. H. Stem cell treatment of dystrophic dogs. Nature 450 10.1038/nature06437 (2007)

  2. Sampaolesi, M. et al. Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs. Nature 444, 574–579 (2006)

    Article  CAS  ADS  Google Scholar 

  3. Kornegay, J. et al. The cranial sartorius muscle undergoes true hypertrophy in dogs with golden retriever muscular dystrophy. Neuromuscul. Disord. 13, 493–500 (2003)

    Article  Google Scholar 

  4. De Luca, A. et al. A multidisciplinary evaluation of the effectiveness of cyclosporine A in dystrophic mdx mice. Am. J. Pathol. 166, 477–489 (2005)

    Article  CAS  Google Scholar 

  5. St-Pierre, S. J. G. et al. Glucocorticoid treatment alleviates dystrophic myofiber pathology by activation of the calcineurin/NF-AT pathway. FASEB J. 18, 1937–1939 (2004)

    Article  CAS  Google Scholar 

  6. Stupka, N. et al. The calcineurin signal transduction pathway is essential for successful muscle regeneration in mdx dystrophic mice. Acta Neuropathol. (Berl.) 107, 299–310 (2004)

    Article  CAS  Google Scholar 

  7. Parsons, S. A. et al. Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy. J. Biol. Chem. 282, 10068–10078 (2007)

    Article  CAS  Google Scholar 

  8. Dell’Agnola, C. et al. Hematopoietic stem cell transplantation does not restore dystrophin expression in Duchenne muscular dystrophy dogs. Blood 104, 4311–4318 (2004)

    Article  Google Scholar 

  9. Schatzberg, S. J. et al. Alternative dystrophin gene transcripts in golden retriever muscular dystrophy. Muscle Nerve 21, 991–998 (1998)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. *San Raffaele Scientific Institute, Stem Cell Research Institute, Via Olgettina 58, 20132 Milan, Italy. cossu.giulio@hsr.it,

    Maurilio Sampaolesi & Giulio Cossu

  2. †Neurobiology Laboratory, Ecòle Veterinaire d’Alfort, 7 Avenue General de Gaulle, 94704 Maisons-Alfort, cedex, France,

    Stephane Blot

  3. ‡Department of Experimental Medicine University of Pavia, Via Forlanini 6-8, 27100 Pavia, Italy,

    Roberto Bottinelli

Authors
  1. Maurilio Sampaolesi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stephane Blot
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Roberto Bottinelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Giulio Cossu
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sampaolesi, M., Blot, S., Bottinelli, R. et al. Sampaolesi et al. reply. Nature 450, E23–E25 (2007). https://doi.org/10.1038/nature06438

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature06438

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing