West nile virus articles within Nature

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• Letter | 17 June 2016

  A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

  Components of the endoplasmic-reticulum-associated signal peptidase complex is required for infection by numerous flaviviruses, including West Nile, dengue and Zika viruses, but is not required for infection by other types of virus or for host protein synthesis.

  • Rong Zhang
  • , Jonathan J. Miner
  •  & Michael S. Diamond

• Letter | 17 November 2010

  2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

  Many cellular and virus messenger RNAs are methylated at the 2′-O positions of the 5′ guanosine cap. The role of 2′-O methylation in virus infection has been unclear. These authors show that this form of methylation enables several unrelated viruses to evade the antiviral effects of genes stimulated by type I interferon.

  • Stephane Daffis
  • , Kristy J. Szretter
  •  & Michael S. Diamond