Article
|
Open Access
Featured
-
-
Article
| Open Access
Intermediate conformations of CD4-bound HIV-1 Env heterotrimers
Single-particle cryo-electron microscopy structures of HIV-1 envelope (Env) trimers bound to one or two CD4 receptors identify intermediate Env conformations that precede host–virus fusion and inform the design of therapeutics to prevent HIV-1 infection.
- Kim-Marie A. Dam
- , Chengcheng Fan
- & Pamela J. Bjorkman
-
Article
| Open Access
Structural atlas of a human gut crassvirus
A cryo-electron microscopy reconstruction of the virus ΦcrAss001 provides insights into the functions of the viral gene products in capsid assembly and infection.
- Oliver W. Bayfield
- , Andrey N. Shkoporov
- & Alfred A. Antson
-
Article |
Structure of the human metapneumovirus polymerase phosphoprotein complex
A cryo-electron microscopy reconstruction shows the ring-shaped structure of the polymerase and capping domains of the L protein bound to a tetramer of phosphoprotein P of the human metapneumovirus.
- Junhua Pan
- , Xinlei Qian
- & Julien Lescar
-
Letter |
Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus
The cryo-electron microscopy structure of the bacteriophage ɸ6 dsRNA genome shows that the genome is packaged in a spooled manner that is more similar to dsDNA viruses than to other dsRNA viruses.
- Serban L. Ilca
- , Xiaoyu Sun
- & Juha T. Huiskonen
-
Letter |
Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome
Cryo-electron microscopy structures of the herpesvirus capsid including the viral genome reveal ordered DNA structures and structural features of the capsid that suggest possible mechanisms for viral genome encapsidation.
- Yun-Tao Liu
- , Jonathan Jih
- & Z. Hong Zhou
-
Letter |
Calicivirus VP2 forms a portal-like assembly following receptor engagement
Cryo-electron microscopy structures of feline calicivirus and its cellular receptor show that twelve copies of the minor capsid protein VP2 form a portal-like assembly arranged about a pore in the capsid shell.
- Michaela J. Conley
- , Marion McElwee
- & David Bhella
-
Letter |
Structure and assembly of the Ebola virus nucleocapsid
Application of cryo-electron tomography and subtomogram averaging to determine the structure of the Ebola virus nucleocapsid within intact viruses and recombinant nucleocapsid-like assemblies.
- William Wan
- , Larissa Kolesnikova
- & John A. G. Briggs
-
Letter |
Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike
New high-resolution cryo-electron microscopy structures of the HIV-1 envelope protein provide a detailed description and understanding of how the HIV-1 fusion machinery functions and how it changes its structure over time to convert from the pre-fusion to the fusion-intermediate conformation.
- Gabriel Ozorowski
- , Jesper Pallesen
- & Andrew B. Ward
-
Letter |
In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus
This study visualizes the interior of a dsRNA virus using cryo-electron microscopy, revealing the organization of the genome of cytoplasmic polyhedrosis virus together with its transcriptional enzyme complex in both quiescent and transcribing states.
- Xing Zhang
- , Ke Ding
- & Z. Hong Zhou
-
Letter |
Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolution
Cryo-electron tomography and subtomogram averaging methods reveal the structure of the capsid lattice within intact heterogeneous immature HIV-1 particles.
- Florian K. M. Schur
- , Wim J. H. Hagen
- & John A. G. Briggs
-
News |
Hot spring yields hybrid genome
Researchers discover natural chimaeric DNA-RNA virus.
- Helen Thompson
-
News |
How 1918 flu antibodies fend off swine flu
Structural similarities reveal why some elderly people were spared in the recent pandemic.
- Heidi Ledford
Structures of the promoter-bound respiratory syncytial virus polymerase