Vasodilation articles within Nature Communications

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  • Article
    | Open Access

    In mammals, hypoxia causes dilation of small arteries for increased metabolic demand. Keller et al used novel transgenic mice to show alpha hemoglobin in endothelium, once thought only in red blood cells, can regulate hypoxic-mediated dilation.

    • T. C. Stevenson Keller IV
    • , Christophe Lechauve
    •  & Brant E. Isakson

  • Article
    | Open Access

    Monitoring hemodynamics in the brain is important in understanding medical imaging data and mechanisms of disease. Here the authors use high-throughput two-photon microscopy with an axially-extended Bessel focus to measure vessel size and blood flow down to capillary scale in the awake mouse brain.

    • Jiang Lan Fan
    • , Jose A. Rivera
    •  & Na Ji

  • Article
    | Open Access

    Early stages of the novel coronavirus disease (COVID-19) have been associated with silent hypoxia and poor oxygenation despite relatively small fractions of afflicted lung. Here, the authors present a mathematical model which reproduces the vascular pulmonary mechanisms observed in patients with early COVID-19.

    • Jacob Herrmann
    • , Vitor Mori
    •  & Béla Suki

  • Article
    | Open Access

    TNF is typically viewed as an inflammatory mediator. Here the authors identify a non-inflammatory mechanism conserved across species whereby the constitutively expressed smooth muscle cell TNF mediates myogenic signal transduction in skeletal muscle resistance arteries and regulates mean arterial blood pressure.

    • Jeffrey T. Kroetsch
    • , Andrew S. Levy
    •  & Steffen-Sebastian Bolz

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