Vasodilation articles within Nature

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• Article | 12 September 2019

  Structural insights into the mechanism of human soluble guanylate cyclase

  Cryo-electron microscopy structures of human soluble guanylate cyclase in inactive and activated states shed light on the activation mechanism of this enzyme by nitric oxide.

  • Yunlu Kang
  • , Rui Liu
  •  & Lei Chen

• Letter | 22 December 2010

  S-glutathionylation uncouples eNOS and regulates its cellular and vascular function

  The enzyme eNOS is crucial for regulating vascular function as it can produce both the vasodilator nitric oxide and the vasoconstrictor superoxide. Here it is shown that a modification associated with oxidant stress, S-glutathionylation, switches the enzyme from forming nitric oxide to forming superoxide. In hypertensive vessels, S-glutathionylation of eNOS is increased and this is associated with impaired endothelium-dependent vasodilation.

  • Chun-An Chen
  • , Tse-Yao Wang
  •  & Jay L. Zweier