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| Open AccessAn ultrasensitive and broadband transparent ultrasound transducer for ultrasound and photoacoustic imaging in-vivo
Transparent ultrasound transducers suffer from practical limitations due to acoustic impedance mismatch. By using a transparent adhesive based on silicon dioxide epoxy, the authors demonstrate a broadband, ultrasensitive transparent ultrasound transducer, advancing the possibilities of sensor fusion.
- Seonghee Cho
- , Minsu Kim
- & Chulhong Kim
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| Open AccessSonogenetic control of multiplexed genome regulation and base editing
Exogenous control of genes in vivo is important. Here the authors report a system that can be inducibly activated through thermal energy produced by ultrasound absorption and use this to control induction of gene activation and base editing: they apply this in cell lines and in a mouse model.
- Pei Liu
- , Josquin Foiret
- & Lei S. Qi
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| Open AccessDeep optoacoustic localization microangiography of ischemic stroke in mice
Optoacoustic super-resolution at millimeter-scale depths has been impeded by the strong background absorption from blood cells. Here, the authors use dichloromethane microdroplets with high optical absorption and demonstrate 3D microangiography of the mouse brain via optoacoustic localization.
- Xosé Luís Deán-Ben
- , Justine Robin
- & Daniel Razansky
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| Open AccessHybrid photoacoustic and fast super-resolution ultrasound imaging
Dual photoacoustic and fast super-resolution ultrasound imaging technique bridges the physiological and structural details in vivo. The authors demonstrated that this interleaved technology allows revealing the transient changes of blood flow and blood oxygenation over time.
- Shensheng Zhao
- , Jonathan Hartanto
- & Yun-Sheng Chen
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| Open AccessClinically translatable quantitative molecular photoacoustic imaging with liposome-encapsulated ICG J-aggregates
Photoacoustic imaging is limited by a lack of contrast agents which can enable combined molecular and physiological imaging at depth. Here the authors address these limitations by developing and validating a contrast agent based on targeted liposomes loaded with J-aggregated indocyanine green dye.
- Cayla A. Wood
- , Sangheon Han
- & Richard R. Bouchard
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| Open AccessLead halide perovskite for efficient optoacoustic conversion and application toward high-resolution ultrasound imaging
Lead halide perovskites are widely used e.g. in solar cells and LEDs, but devices based on thermal properties have received little attention. Here, the authors take advantage of the thermal properties to fabricate an optoacoustic transducer with both broad bandwidth and high conversion efficiency.
- Xinyuan Du
- , Jiapu Li
- & Jiang Tang
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| Open AccessReal-time interleaved spectroscopic photoacoustic and ultrasound (PAUS) scanning with simultaneous fluence compensation and motion correction
Spectroscopic photoacoustic imaging has been limited by wavelength-dependent fluence variations and tissue motion. Here, the authors achieve real-time fluence and motion correction in vivo by using a wavelength-tunable laser, sequential scan of a narrow beam and partial image reconstruction for each pulse.
- Geng-Shi Jeng
- , Meng-Lin Li
- & Matthew O’Donnell
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| Open AccessSub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens
Traditional methods for ultrasound detection in biomedical application suffer from limited lateral resolution. Here, the authors show that a phononic metamaterial lens can be used for spatial characterisation of subwavelength objects, even beyond the Fresnel zone of the emitting transducer.
- Ezekiel L. Walker
- , Yuqi Jin
- & Arup Neogi
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| Open AccessTransfer functions linking neural calcium to single voxel functional ultrasound signal
Neurovascular coupling refers to changes in cerebral blood flow in response to neuronal stimulation, but to what extent this change can report neuronal activation is not known. Here the authors develop transfer functions between neural calcium signals and functional ultrasound changes in blood volume in co-registered single voxel brain volumes.
- Ali-Kemal Aydin
- , William D. Haselden
- & Davide Boido
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| Open AccessFunctional ultrasound imaging of the brain reveals propagation of task-related brain activity in behaving primates
Neuroimaging modalities such as MRI and EEG are able to record brain activity, but spatiotemporal resolution and sensitivity are limited. Here, the authors show how a recently developed method, functional ultrasound imaging (fUS), can measure brain activation during cognitive tasks in primates.
- Alexandre Dizeux
- , Marc Gesnik
- & Mickael Tanter
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Article
| Open AccessNoninvasive sub-organ ultrasound stimulation for targeted neuromodulation
Stimulation of peripheral nerve activity may be used to treat metabolic and inflammatory disorders, but current approaches need implanted devices. Here, the authors present a non-invasive approach, and show that ultrasound-mediated stimulation can be targeted to specific sub-organ locations in preclinical models and alter the response of metabolic and inflammatory neural pathways.
- Victoria Cotero
- , Ying Fan
- & Christopher Puleo
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Article
| Open AccessNoninvasive ultrasound stimulation of the spleen to treat inflammatory arthritis
Modulation of the cholinergic pathway and spleen function can reduce inflammation with invasive implants. Here, the authors show that non-invasive ultrasound stimulation of the spleen reduces disease severity in a mouse model of inflammatory arthritis, partly via altering B and T cell function.
- Daniel P. Zachs
- , Sarah J. Offutt
- & Hubert H. Lim
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Article
| Open AccessMesoscopic and microscopic imaging of sensory responses in the same animal
Neuronal activity leads to a local increase in blood flow and volume, a process termed hyperaemia. Here, the authors employ multiple imaging approaches of neuronal and vascular activity at varying resolution to delineate the spatiotemporal dynamics of neurovascular coupling evoked by odours in the olfactory bulb.
- Davide Boido
- , Ravi L. Rungta
- & Serge Charpak
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| Open AccessSmall near-infrared photochromic protein for photoacoustic multi-contrast imaging and detection of protein interactions in vivo
Bacterial phytochrome-based probes improved sensitivity in photoacoustic computed tomography. Here the authors engineer a small near-infrared switchable photochromic probe that allows multi-contrast imaging at depths and can be adapted to study protein–protein interactions in deep-seated tumors.
- Lei Li
- , Anton A. Shemetov
- & Vladislav V. Verkhusha
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Article
| Open AccessMultifunctional nanoparticles as a tissue adhesive and an injectable marker for image-guided procedures
The use of tissue adhesives for the closure of wounds is of growing interest for surgery and trauma management. Here, the authors develop an adhesive that is biocompatible, enables tissue adhesion and also permits real-time imaging due to the presence of contrast agents for multiple modalities.
- Kwangsoo Shin
- , Jin Woo Choi
- & Taeghwan Hyeon
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| Open AccessHigh-speed ultrasound imaging in dense suspensions reveals impact-activated solidification due to dynamic shear jamming
Suspensions of particles at high volume fractions are subject to discontinuous shear thickening or even turn into solid upon impact, yet the underlying mechanism remains elusive. Here, Han et al. follow the propagation of shear bands at jamming fronts in three dimensions and show no sign of densification.
- Endao Han
- , Ivo R. Peters
- & Heinrich M. Jaeger
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Biomedical photoacoustics beyond thermal expansion using triggered nanodroplet vaporization for contrast-enhanced imaging
A dual-contrast agent has been developed for combined ultrasound and photoacoustic imaging. This agent uses vaporization for ultrasound contrast enhancement and photoacoustic signal generation, providing significantly higher signals than thermal expansion, the most commonly used photoacoustic mechanism.
- Katheryne Wilson
- , Kimberly Homan
- & Stanislav Emelianov