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Cortical responses to touch reflect subcortical integration of LTMR signals
Genetic manipulation of skin peripheral sensory neurons in mice shows that cortical neuron responses to touch reflect subcortical mixing of signals from both rapidly adapting and slowly adapting low-threshold mechanoreceptors.
- Alan J. Emanuel
- , Brendan P. Lehnert
- & David D. Ginty
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Parallel ascending spinal pathways for affective touch and pain
Two populations of neurons with distinct anatomy and receptor expression that convey information from the spinal cord to the brain have different functional properties with respect to touch and pain.
- Seungwon Choi
- , Junichi Hachisuka
- & David D. Ginty
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Letter |
Sensing with tools extends somatosensory processing beyond the body
Tools are embodied by the human somatosensory system, serving as sensory extensions of the human body.
- Luke E. Miller
- , Luca Montroni
- & Alessandro Farnè
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Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
The mechanoreceptor Piezo2 is required for both the Hering–Breuer inflation reflex in adult mice and the inflation of the lungs of newborn mice.
- Keiko Nonomura
- , Seung-Hyun Woo
- & Ardem Patapoutian
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Letter |
Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors
The cellular basis of touch has long been debated, in particular the relationship between sensory neurons and non-neuronal cells; a mouse study uses optogenetics to identify their distinct and collaborative roles, with skin-derived Merkel cells both transducing touch and actively tuning responses of touch-sensitive neurons.
- Srdjan Maksimovic
- , Masashi Nakatani
- & Ellen A. Lumpkin
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Letter |
Piezo2 is required for Merkel-cell mechanotransduction
A mouse study shows that non-neuronal epidermal Merkel cells aid fine-touch perception in the skin through their expression of the Piezo2 mechanosensitive cation channel which then actively tunes the response to touch in adjacent somatosensory neurons.
- Seung-Hyun Woo
- , Sanjeev Ranade
- & Ardem Patapoutian