Thrombopoiesis articles within Nature

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• Letter | 22 March 2017

  The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

  Direct imaging of the lung microcirculation in mice indicates that it is a major site of mature platelet production from megakaryocytes.

  • Emma Lefrançais
  • , Guadalupe Ortiz-Muñoz
  •  & Mark R. Looney

• Article | 30 November 2011

  New gene functions in megakaryopoiesis and platelet formation

  A meta-analysis of genome-wide association studies in more than 66,000 individuals identifies 68 new genomic loci that reliably associate with platelet count and volume, and reveals new gene functions.

  • Christian Gieger
  • , Aparna Radhakrishnan
  •  & Nicole Soranzo

• Research Highlights | 02 November 2011

  Immune system's bacterial shepherd

• Letter | 19 August 2010

  A mechanically stabilized receptor–ligand flex-bond important in the vasculature

  Here, a new type of behaviour of receptor–ligand bonds has been identified, by using a new method that links receptor and ligand in a single molecule to measure binding and unbinding. The binding of von Willebrand factor to the glycoprotein Ib α subunit on the surface of platelets is important for coagulation. This receptor–ligand bond is now shown to have two distinct states, one seen at low force and a second that has greater force resistance. This has implications for how increased blood flow activates platelet plug formation.

  • Jongseong Kim
  • , Cheng-Zhong Zhang
  •  & Timothy A. Springer