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Mechanical actions of dendritic-spine enlargement on presynaptic exocytosis
A mechanism of mechanosensation and transduction in the presynaptic boutons is identified, in which sensing of fine pressure leads to enhanced neurotransmitter release.
- Hasan Ucar
- , Satoshi Watanabe
- & Haruo Kasai
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Letter |
Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties
Analysis at high temporal and spatial resolution shows that the number and dynamics of SNARE proteins available during exocytosis determines the size and stability of fusion pores.
- Huan Bao
- , Debasis Das
- & Edwin R. Chapman
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Letter |
Retrograde semaphorin–plexin signalling drives homeostatic synaptic plasticity
At the neuromuscular junction in Drosophila, signalling from postsynaptic Sema2b to presynaptic PlexB controls presynaptic homeostatic plasticity through Mical-mediated regulation of the readily releasable pool of synaptic vesicles.
- Brian O. Orr
- , Richard D. Fetter
- & Graeme W. Davis
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The primed SNARE–complexin–synaptotagmin complex for neuronal exocytosis
An atomic model of the primed pre-fusion SNARE–complexin–synaptotagmin-1 complex in neuronal exocytosis accounting for vesicle priming and cooperation in synchronizing and activating evoked release on the sub-millisecond timescale.
- Qiangjun Zhou
- , Peng Zhou
- & Axel T. Brunger
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Letter |
The calcium sensor synaptotagmin 7 is required for synaptic facilitation
Synaptotagmin 7 is shown to be essential for synaptic facilitation at a variety of central synapses, and the results pave the way for future functional studies of short-term synaptic plasticity, a fundamental form of neuronal computation.
- Skyler L. Jackman
- , Josef Turecek
- & Wade G. Regehr
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Article |
Ultrafast endocytosis at mouse hippocampal synapses
Sustained neurotransmission requires recycling of synaptic vesicles, but the proposed mechanisms have been controversial; here a ‘flash-and-freeze’ method for electron microscopy reveals a new ultrafast form of endocytosis that is actin- and dynamin-dependent and occurs within 100 milliseconds of stimulation.
- Shigeki Watanabe
- , Benjamin R. Rost
- & Erik M. Jorgensen
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Letter |
α2δ expression sets presynaptic calcium channel abundance and release probability
The voltage-gated calcium channel protein subunit α2δ is shown to control both the abundance of voltage-gated calcium channels and their coupling to the vesicular release of neurotransmitters into the synapse; because the α2δ family is a known target of potent analgesics, this study offers a new link between basic synaptic physiology and pain research in the clinic.
- Michael B. Hoppa
- , Beatrice Lana
- & Timothy A. Ryan
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Letter |
Membrane protein sequestering by ionic protein–lipid interactions
- Geert van den Bogaart
- , Karsten Meyenberg
- & Reinhard Jahn
Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides