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A Fabry-Pérot cavity coupled surface plasmon photodiode for electrical biomolecular sensing
Surface plasmon resonance is well established for biosensing applications, but commonly limited by complex optical detection. Here, the authors present a plasmonic sensor integrated in a photovoltaic cell, which generates an electronic signal sensitive to the solution refractive index via plasmon interaction
- Giles Allison
- , Amrita Kumar Sana
- & Hironori Suzuki
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Article
| Open Access
High-spatial and colourimetric imaging of histone modifications in single senescent cells using plasmonic nanoprobes
The authors demonstrate a colourimetric imaging method using plasmonic nanoparticles for visualisation of heterochromatin histone markers. Based on the distance-dependent coupling effect, resulting in spectral shifts, they observe reorganisation of histone markers caused by oncogene-induced senescence.
- Hyun Ji An
- , Yun Kim
- & Inhee Choi
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Article
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Ultrasensitive antibody-aptamer plasmonic biosensor for malaria biomarker detection in whole blood
Reliable plasmonic biosensors with high throughput and ease of use are highly sought after. Here, the authors report a plasmon-enhanced fluorescence antibody-aptamer biosensor based on a gold nanoparticle array, and demonstrate its use for effective specific detection of a malaria marker, at femtomolar level, in whole blood.
- Antonio Minopoli
- , Bartolomeo Della Ventura
- & Raffaele Velotta
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Article
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Single gold-bridged nanoprobes for identification of single point DNA mutations
The identification of single point mutations is an important step toward personalizing detection and treatment. Here the authors design a gold-bridged nanoparticle for sensing MutS affinities to point mutations, and compile an atlas of the affinity data for detecting BRCA1 mutations in cell lines.
- Xingyi Ma
- , Sojin Song
- & Sang Jun Sim
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Article
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Non plasmonic semiconductor quantum SERS probe as a pathway for in vitro cancer detection
Surface enhanced Raman scattering is a bio-analytical tool and the development and optimisation of probes is an active area of investigation. Here, the authors report on the development and testing of biocompatible semiconductor zinc oxide quantum probes on a platform for cell adhesion and analysis.
- Rupa Haldavnekar
- , Krishnan Venkatakrishnan
- & Bo Tan
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Article
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Cellular imaging by targeted assembly of hot-spot SERS and photoacoustic nanoprobes using split-fluorescent protein scaffolds
Traditional methods for the assembly of plasmonic nanoparticles into photo-responsive probes suffer from multiple problems. Here the authors use split fluorescent protein fragments as molecular glue to form stable nanoclusters for surface enhanced Raman scattering and photoacoustic imaging in live cells.
- Tuğba Köker
- , Nathalie Tang
- & Fabien Pinaud
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Article
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Imaging the transient heat generation of individual nanostructures with a mechanoresponsive polymer
Remote thermometers with a high spatiotemporal resolution are very desirable for applications in the life sciences, including photothermal therapy. Here, Chen et al. develop polymer coated gold nanorods with a temperature sensitivity of 80 mK and a 4 ms response time for thermometry in the life sciences.
- Xueqin Chen
- , Qing Xia
- & Jun-Jie Zhu
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Ultrasensitive and label-free molecular-level detection enabled by light phase control in magnetoplasmonic nanoantennas
Ferromagnetic nanoantennas support plasmons and exhibit magneto-optical activity under external magnetic fields. Maccaferri et al. show how designed phase compensation in the electric response of these nanostructures enables them to act as ultrasensitive label-free molecular sensors with high figures of merit.
- Nicolò Maccaferri
- , Keith E. Gregorczyk
- & Paolo Vavassori
Flexible hyperspectral surface plasmon resonance microscopy