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| Open AccessVentral striatal islands of Calleja neurons bidirectionally mediate depression-like behaviors in mice
Ventral striatal Islands of Calleja neurons, known to regulate grooming in mice, are reported to bidirectionally mediate depression-like behaviors. Here, authors link grooming, dopamine signaling and affective behaviors via ventral striatal circuits.
- Yun-Feng Zhang
- , Jialiang Wu
- & Minghong Ma
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| Open AccessKetamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice
Intravenous infusion of ketamine rapidly reduces obsessive-compulsive disorder symptoms. Here, the authors show in mice that ketamine acts by increasing activity in a fronto-striatal circuit that causally controls compulsive grooming behaviour.
- Gwynne L. Davis
- , Adelaide R. Minerva
- & Lisa A. Gunaydin
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| Open AccessVentral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice
Acute stress transiently disrupts reward-seeking behaviour and repeated stress exposure produces lasting anhedonia-like behaviour in rodents. Here, the authors show that stress triggers GABAergic activity in the ventral tegmental area which blunts reward-seeking behaviour in mice.
- Daniel C. Lowes
- , Linda A. Chamberlin
- & Alexander Z. Harris
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| Open AccessCocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation
Drugs of abuse have been shown to perturb circadian rhythms. Here, the authors show in mice that cocaine exposure modulates circadian gene expression in the striatum through a previously unappreciated pathway that involves dopamine D2 receptors and the nuclear receptor PPARγ.
- Karen Brami-Cherrier
- , Robert G. Lewis
- & Emiliana Borrelli
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| Open AccessDifferential processing of thalamic information via distinct striatal interneuron circuits
The responses of striatal GABAergic interneurons to thalamic inputs are not well characterised. Here, the authors demonstrate that complex intrastriatal circuitry is responsible for thalamic-evoked monosynaptic and disynaptic excitation in NPY-NGF interneurons but a disynaptic inhibition in the NPY-PLTS.
- Maxime Assous
- , Jaime Kaminer
- & James M. Tepper
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| Open AccessBasolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits
Drug seeking behaviour has habitual neural substrates. Here, Murray et al. show that the basolateral amygdala and central nucleus of the amygdala are necessary to recruit and maintain, respectively, the intrastriatal functional transition that underlies cocaine seeking habits.
- Jennifer E. Murray
- , Aude Belin-Rauscent
- & David Belin
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| Open AccessCorticostriatal pathways contribute to the natural time course of positive mood
Positive mood can occur as a result of a stimulus or spontaneously. Admon and Pizzagalli measure variations in neural responses to a positive stimulus over time, and identify cortico-striatal interactions associated with sustained positive mood which are reduced in individuals with a history of depression.
- Roee Admon
- & Diego A. Pizzagalli
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| Open AccessDARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons
Changes in environment are known to alter reward system responses, although the underlying mechanisms are unclear. Here, Engmann et al.show that DARPP-32 interacts directly with β-adducin in the mouse striatum to regulate structural and behavioural plasticity in response to novel environment and drug exposure.
- Olivia Engmann
- , Albert Giralt
- & Jean-Antoine Girault
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| Open AccessInsulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward
Insulin signals satiety after a meal; however, the rising incidence of obesity and chronic insulin elevation suggests that insulin may also signal reward. Here, Stouffer et al. show that insulin amplifies dopamine release in rodent striatum depending on diet, and that striatal insulin can influence food choice.
- Melissa A. Stouffer
- , Catherine A. Woods
- & Margaret E. Rice
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| Open AccessTwo spatiotemporally distinct value systems shape reward-based learning in the human brain
Learning to reinforce rewarding decisions and avoiding repeated mistakes is critical, yet the neural systems mediating feedback processing in value-guided choices remain elusive. Here the authors uncover the spatiotemporal dynamics of two separate but interacting value systems during learning.
- Elsa Fouragnan
- , Chris Retzler
- & Marios G. Philiastides
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| Open AccessContextual modulation of value signals in reward and punishment learning
In contrast to predictions from learning theory, humans learn to seek rewards and avoid punishments equally well. Here the authors offer an elegant solution to this problem by demonstrating that humans learn option values relative to a reference point subserved by a common neural substrate.
- Stefano Palminteri
- , Mehdi Khamassi
- & Giorgio Coricelli
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Orbitofrontal lesions eliminate signalling of biological significance in cue-responsive ventral striatal neurons
The ventral striatum (VS) has long been proposed as crucial for integrating biologically significant associative information to drive actions. Here, the authors demonstrate that orbitofrontal cortical inputs to the VS play a critical role in biasing activity to represent reward value.
- Nisha K. Cooch
- , Thomas A. Stalnaker
- & Geoffrey Schoenbaum
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Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum
Voltage-gated Na+ channel β-subunits are concentrated in the nodes of Ranvier and axon initial segments of myelinated axons and have a variety of functions. Here the authors show, using genetically modified mice, that this subunit is present in unmyelinated fibres in the striatum and is required for generation of resurgent Na+ current in striatal neurons.
- Haruko Miyazaki
- , Fumitaka Oyama
- & Nobuyuki Nukina
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| Open AccessBalanced activity in basal ganglia projection pathways is critical for contraversive movements
The striatum is required for evoking contraversive movements from each brain hemisphere, but it is unclear how. Here, Tecuapetla et al.use optogenetics to inhibit direct and indirect downstream striatal projection pathways, and show that activity in both pathways is necessary for contraversive movements.
- Fatuel Tecuapetla
- , Sara Matias
- & Rui M. Costa