Sphingolipids articles within Nature Communications

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  • Article
    | Open Access

    Sphingolipids are structural membrane components produced by the serine palmitoyl transferase (SPT). Here, the authors solved the cryo EM structure of the ceramide bound yeast SPOTS complex. This explains how ceramide regulates the activity of the yeast SPT complex.

    • Jan-Hannes Schäfer
    • , Carolin Körner
    •  & Florian Fröhlich

  • Article
    | Open Access

    Metabolites play an important role in physiology, yet the complexity of the metabolome and its interaction with disease and aging is poorly understood. Here the authors present a comprehensive atlas of the mouse brain metabolome and how it changes during aging.

    • Jun Ding
    • , Jian Ji
    •  & Oliver Fiehn

  • Article
    | Open Access

    The mechanisms by which platelets release sphingosine-1-phosphate (S1P) is not well characterized. Here the authors show that Mfsd2b is required for S1P release from both resting and activated platelets and that deletion of Mfsd2b impairs thrombotic functions of platelets.

    • Madhuvanthi Chandrakanthan
    • , Toan Quoc Nguyen
    •  & Long N. Nguyen

  • Article
    | Open Access

    Zika virus (ZIKV) remodels intracellular membranes for replication, but the role of different lipid types for infection and disease is unclear. Here, the authors perform lipidomics, show perturbation of the lipid network during ZIKV infection and show that ceramides are important for ZIKV infection.

    • Hans C. Leier
    • , Jules B. Weinstein
    •  & Fikadu G. Tafesse

  • Article
    | Open Access

    Ceramides are lipids that act directly on mitochondria to trigger apoptosis, but the underlying mechanism remains largely unclear. Here authors use a photoactivatable ceramide probe combined with a computation approach and functional studies to identify the voltage-dependent anion channel VDAC2 as a direct effector of ceramide-mediated cell death.

    • Shashank Dadsena
    • , Svenja Bockelmann
    •  & Joost C. M. Holthuis

  • Article
    | Open Access

    Ceramides are important participants of signal transduction, regulating fundamental cellular processes. Here authors show that C16-ceramide binds to the tumor suppressor p53, disrupts its interaction with MDM2 and facilitates p53 accumulation and activation of its downstream targets.

    • Baharan Fekry
    • , Kristen A. Jeffries
    •  & Natalia I. Krupenko

  • Article
    | Open Access

    Ceramides are signalling molecules that regulate several physiological functions including insulin sensitivity. Here the authors report a selective ceramide synthase 1 inhibitor that counteracts lipid accumulation within the muscle and adiposity by increasing fatty acid oxidation but without affecting insulin sensitivity in mice fed with an obesogenic diet.

    • Nigel Turner
    • , Xin Ying Lim
    •  & Anthony S. Don

  • Article
    | Open Access

    Loss-of-function mutations in an enzyme of unknown function, PNPLA1, cause dry and scaling skin in humans. Here Ohnoet al. show that PNPLA1 is a transacylase that acts in the final step of acylceramide production- esterification between ω-hydroxyceramide and linoleic acid acylceramide, yielding a lipid essential for skin barrier function.

    • Yusuke Ohno
    • , Nozomi Kamiyama
    •  & Akio Kihara

  • Article
    | Open Access

    Loss-of-function mutations inPNPLA1, a gene encoding an enzyme with unknown function, cause dry and scaling skin in humans. Using mouse models with PNPLA1 deficiency, the authors show that PNPLA1 participates in the biosynthesis of acylceramide, a lipid component essential for skin barrier function.

    • Tetsuya Hirabayashi
    • , Tatsuki Anjo
    •  & Makoto Murakami

  • Article
    | Open Access

    The presence of the signalling lipid Sphingosine 1-phosphate (S1P) in erythrocytes has unclear physiological implications. Here the authors show that the S1P-generating enzyme Sphingosine kinase type 1 and its product S1P play an important role in the red blood cell adaptation to hypoxic environments in mice and humans.

    • Kaiqi Sun
    • , Yujin Zhang
    •  & Yang Xia

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