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| Open AccessAsynchronous glutamate release is enhanced in low release efficacy synapses and dispersed across the active zone
Neurotransmitters can be released with a delay in relation to action potentials. This work demonstrates how this asynchronous release is related to overall vesicle release probability and short-term plasticity.
- Philipe R. F. Mendonça
- , Erica Tagliatti
- & Kirill E. Volynski
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Article
| Open AccessTranssynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses
Post‐tetanic potentiation (PTP) is a major form of plasticity at hippocampal mossy fiber synapses and is considered an entirely presynaptic phenomenon. The authors show that mossy fiber PTP not only lacks associativity, but rather shows anti‐associative induction properties, implementing a brake on mossy fiber detonation.
- David Vandael
- , Yuji Okamoto
- & Peter Jonas
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Article
| Open AccessReduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia
Stein, Barbosa et al. show that anti-NMDAR encephalitis and schizophrenia are characterized by reduced serial dependence in spatial working memory. Cortical network simulations show that this can be parsimoniously explained by a reduction in NMDAR-dependent short-term synaptic potentiation in these diseases.
- Heike Stein
- , Joao Barbosa
- & Albert Compte
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Article
| Open AccessPresenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity
Mutations in presenilin, which cleaves amyloid precursor protein, cause familial Alzheimer’s Disease. Here, the authors show that loss of presenilin leads to loss of synaptotagmin 7, leading to impaired presynaptic release.
- Gaël Barthet
- , Tomàs Jordà-Siquier
- & Christophe Mulle
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Article
| Open AccessCKAMP44 modulates integration of visual inputs in the lateral geniculate nucleus
The function of receptor desensitization in vivo is not well understood. Here, the authors show that deletion of CKAMP44, an AMPAR auxiliary protein that modulates desensitization of AMPAR currents, affects synaptic facilitation at retinogeniculate synapses and visually-evoked firing in awake mice.
- Xufeng Chen
- , Muhammad Aslam
- & Jakob von Engelhardt